Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRM1 | P35372 | 2/20 | 0.38 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.38 |
| ▸ | OPRL1 | P41146 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.37 |
| ▸ | MAPT | P10636 | 2/20 | 0.37 |
| ▸ | HTR1E | P28566 | 1/20 | 0.37 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.37 |
| ▸ | S1PR3 | Q99500 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | CCR2 | P41597 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | MAOB | P27338 | 3/20 | 0.35 |
| ▸ | MAOA | P21397 | 1/20 | 0.35 |
| ▸ | AKR1C1 | Q04828 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7915820 | 0.84 | LMNA (0.40) | OPRM1SMN1; SMN2KMT2AMAPTHTR1E | |
| SCHEMBL6036843 | 0.83 | AKR1C1 (0.52) | OPRM1OPRK1OPRL1SMN1; SMN2KMT2A | |
| SCHEMBL6036780 | 0.82 | HDAC4 (0.47) | ALDH1A1HSD11B1CCR2DRD2DRD4 | |
| SCHEMBL9191673 | 0.81 | AKR1C1 (0.50) | OPRM1OPRL1SMN1; SMN2KMT2AHSD11B1 | |
| SCHEMBL10062522 | 0.80 | CA1 (0.38) | OPRM1SMN1; SMN2KMT2AMAPTHTR1E | |
| SCHEMBL26085136 | 0.79 | OPRM1 (0.36) | OPRM1SMN1; SMN2KMT2AMAPTHTR1E | |
| SCHEMBL10062521 | 0.79 | CA1 (0.38) | OPRM1SMN1; SMN2KMT2AMAPTHTR1E | |
| SCHEMBL26958140 | 0.78 | MAPT (0.38) | OPRM1OPRK1SMN1; SMN2KMT2AMAPT | |
| SCHEMBL26941579 | 0.77 | GSK3B (0.40) | OPRM1OPRK1SMN1; SMN2MAPTALDH1A1 | |
| SCHEMBL19753647 | 0.77 | ADORA3 (0.39) | OPRM1OPRK1SMN1; SMN2KMT2AMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1377589-B1 | OXAZOLYL-PYRAZOLE DERIVATIVES AS KINASE INHIBITORS | PHARMACIA ITALIA SPA (IT) | 2005-09-07 | — | — | EP | claimed |