Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.55 |
| ▸ | MAPT | P10636 | 1/20 | 0.55 |
| ▸ | APP | P05067 | 1/20 | 0.47 |
| ▸ | GAA | P10253 | 1/20 | 0.47 |
| ▸ | HCAR3 | P49019 | 1/20 | 0.47 |
| ▸ | HCAR2 | Q8TDS4 | 1/20 | 0.47 |
| ▸ | NPC1 | O15118 | 2/20 | 0.46 |
| ▸ | TP53 | P04637 | 2/20 | 0.46 |
| ▸ | RAB9A | P51151 | 2/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.46 |
| ▸ | F7 | P08709 | 1/20 | 0.46 |
| ▸ | F3 | P13726 | 1/20 | 0.46 |
| ▸ | SARM1 | Q6SZW1 | 1/20 | 0.46 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.46 |
| ▸ | SIRT6 | Q8N6T7 | 1/20 | 0.46 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.46 |
| ▸ | SIRT3 | Q9NTG7 | 1/20 | 0.46 |
| ▸ | SIRT5 | Q9NXA8 | 1/20 | 0.46 |
| ▸ | SIRT4 | Q9Y6E7 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 2/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1628833 | 0.81 | ALDH1A1 (0.78) | ALDH1A1MAPTAPPGAAHCAR3 | |
| SCHEMBL9213948 | 0.81 | ALDH1A1 (0.52) | ALDH1A1MAPTAPPGAAHCAR3 | |
| SCHEMBL30827513 | 0.81 | ALDH1A1 (0.78) | ALDH1A1MAPTAPPGAAHCAR3 | |
| Ammonia Solution, Strong SCHEMBL27461059 | 0.80 | ALDH1A1 (0.76) | ALDH1A1MAPTAPPGAAHCAR3 | |
| Hydrochloric Acid SCHEMBL8066446 | 0.80 | ALDH1A1 (0.76) | ALDH1A1MAPTAPPGAAHCAR3 | |
| SCHEMBL29458655 | 0.80 | ALDH1A1 (0.76) | ALDH1A1MAPTAPPGAAHCAR3 | |
| SCHEMBL6631612 | 0.78 | ALDH1A1 (0.66) | ALDH1A1MAPTAPPGAAHCAR3 | |
| SCHEMBL28520745 | 0.76 | ALDH1A1 (0.62) | ALDH1A1MAPTAPPGAAHCAR3 | |
| SCHEMBL5160958 | 0.75 | PLOD2 (0.59) | ALDH1A1MAPTAPPGAAHCAR3 | |
| SCHEMBL7007267 | 0.74 | ALDH1A1 (0.46) | ALDH1A1MAPTAPPGAAHCAR3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1668601-A | N-substituted tricyclic 3-aminopyrazoles as PDFG receptor inhibitors | JANSSEN PHARMACEUTICA NV (BE) | 2005-09-14 | — | — | CN | disclosed |
| EP-1506175-A1 | N-SUBSTITUTED TRICYCLIC 3-AMINOPYRAZOLES AS PDGF RECEPTOR INHIBITORS | JANSSEN PHARMACEUTICA N.V. (BE) | 2005-02-16 | — | — | EP | disclosed |
| WO-2003097609-A1 | N-SUBSTITUTED TRICYCLIC 3-AMINOPYRAZOLES AS PDFG RECEPTOR INHIBITORS | JANSSEN PHARMACEUTICA N.V. (BE) | 2003-11-27 | — | — | WO | disclosed |