Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2C | P28335 | 3/20 | 0.39 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.38 |
| ▸ | HTR6 | P50406 | 1/20 | 0.37 |
| ▸ | HTR1A | P08908 | 1/20 | 0.37 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.37 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.37 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.37 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.37 |
| ▸ | PIM1 | P11309 | 1/20 | 0.37 |
| ▸ | PIM3 | Q86V86 | 1/20 | 0.37 |
| ▸ | PIM2 | Q9P1W9 | 1/20 | 0.37 |
| ▸ | USP2 | O75604 | 1/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.36 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4308724 | 0.91 | EPHX2 (0.40) | HTR2CEPHX2HTR6HTR1ASLC6A2 | |
| SCHEMBL4311413 | 0.88 | TSHR (0.40) | HTR2CEPHX2ADRB1CYP3A4 | |
| SCHEMBL4315672 | 0.88 | ADRB1 (0.52) | HTR2CHTR6HTR1AADRB1CHRNB2 | |
| SCHEMBL4313451 | 0.88 | KDM4E (0.39) | HTR2CEPHX2HTR6HTR1ASLC6A2 | |
| SCHEMBL2640084 | 0.88 | CHRNB2 (0.49) | HTR2CHTR6ADRB1CHRNB2CHRNA4 | |
| SCHEMBL4320133 | 0.87 | HTR2C (0.42) | HTR2CHTR6ADRB1CHRNB2CHRNA4 | |
| SCHEMBL4325739 | 0.86 | HTR2C (0.38) | HTR2CEPHX2HTR6HTR1ASLC6A2 | |
| SCHEMBL4318628 | 0.86 | HTT (0.42) | KDM4EALDH1A1 | |
| SCHEMBL4316517 | 0.86 | HTR1A (0.53) | HTR2CEPHX2HTR6HTR1ASLC6A2 | |
| SCHEMBL4308710 | 0.86 | CHRNB4 (0.40) | HTR2CHTR1ASLC6A2SLC6A4KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1178973-B1 | PYRAZINYL-PIPERAZINE- COMPOUNDS, THEIR USE AND PREPARATION | BIOVITRUM AB (SE) | 2005-12-21 | — | — | EP | disclosed |