Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD11B1 | P28845 | 7/20 | 0.71 |
| ▸ | NPC1 | O15118 | 1/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.51 |
| ▸ | RECQL | P46063 | 1/20 | 0.50 |
| ▸ | LMNA | P02545 | 1/20 | 0.49 |
| ▸ | GSK3B | P49841 | 1/20 | 0.49 |
| ▸ | POLB | P06746 | 1/20 | 0.48 |
| ▸ | GRK2 | P25098 | 1/20 | 0.48 |
| ▸ | PKM | P14618 | 1/20 | 0.48 |
| ▸ | EGFR | P00533 | 1/20 | 0.48 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6203276 | 0.92 | HSD11B1 (0.83) | HSD11B1NPC1KMT2AKDM4EALDH1A1 | |
| SCHEMBL6199060 | 0.84 | KMT2A (0.73) | HSD11B1NPC1KMT2AKDM4EALDH1A1 | |
| SCHEMBL6223332 | 0.84 | KMT2A (0.73) | HSD11B1NPC1KMT2AALDH1A1RECQL | |
| SCHEMBL28543793 | 0.83 | RECQL (0.71) | HSD11B1NPC1KMT2AALDH1A1RECQL | |
| SCHEMBL10931021 | 0.83 | HSD11B1 (1.00) | HSD11B1NPC1KMT2AKDM4EALDH1A1 | |
| SCHEMBL6201887 | 0.83 | HSD11B1 (0.87) | HSD11B1NPC1KMT2AKDM4EALDH1A1 | |
| SCHEMBL6278347 | 0.83 | HSD11B1 (0.71) | HSD11B1NPC1KMT2AKDM4EALDH1A1 | |
| SCHEMBL6319697 | 0.80 | GSK3B (0.53) | HSD11B1KMT2AALDH1A1RECQLLMNA | |
| SCHEMBL31208424 | 0.76 | HSD11B1 (0.68) | HSD11B1NPC1KMT2AKDM4EALDH1A1 | |
| SCHEMBL29087444 | 0.75 | PLCG1 (0.57) | HSD11B1NPC1KMT2AKDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20050272036-A1 | Ketones | ASTRAZENECA AB (SE) | 2005-12-08 | — | — | US | disclosed |
| EP-1549600-A1 | KETONES | AstraZeneca AB (SE) | 2005-07-06 | — | — | EP | disclosed |
| WO-2004011410-A1 | CHEMICAL COMPOUNDS | ASTRAZENECA AB (SE) | 2004-02-05 | — | — | WO | disclosed |