Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.50 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.50 |
| ▸ | LMNA | P02545 | 2/20 | 0.48 |
| ▸ | CES2 | O00748 | 1/20 | 0.48 |
| ▸ | CES1 | P23141 | 1/20 | 0.48 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.46 |
| ▸ | PGR | P06401 | 1/20 | 0.46 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.46 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.46 |
| ▸ | HTR2A | P28223 | 1/20 | 0.46 |
| ▸ | HRH1 | P35367 | 1/20 | 0.46 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.45 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.45 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | MDM2 | Q00987 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6202507 | 0.86 | SMN1; SMN2 (0.48) | TDP1L3MBTL1LMNACES2CES1 | |
| SCHEMBL6199617 | 0.86 | MAPT (0.53) | TDP1L3MBTL1LMNACES2CES1 | |
| SCHEMBL306216 | 0.83 | APAF1 (0.49) | LMNASMN1; SMN2KMT2AMEN1SIGMAR1 | |
| SCHEMBL536302 | 0.83 | APAF1 (0.49) | LMNASMN1; SMN2KMT2AMEN1SIGMAR1 | |
| SCHEMBL15765595 | 0.81 | SMN1; SMN2 (0.45) | LMNAALDH1A1CYP3A4CYP1A2TSHR | |
| SCHEMBL15711164 | 0.81 | SMN1; SMN2 (0.45) | LMNAALDH1A1CYP3A4CYP1A2TSHR | |
| SCHEMBL22133173 | 0.81 | SMN1; SMN2 (0.45) | LMNAALDH1A1CYP3A4CYP1A2TSHR | |
| Hydrochloric Acid SCHEMBL2552987 | 0.81 | APAF1 (0.47) | LMNASMN1; SMN2KMT2AMEN1SIGMAR1 | |
| Hydrochloric Acid SCHEMBL304495 | 0.81 | APAF1 (0.47) | LMNASMN1; SMN2KMT2AMEN1SIGMAR1 | |
| SCHEMBL6202101 | 0.81 | MEP1B (0.57) | TDP1L3MBTL1LMNACES2CES1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20050272036-A1 | Ketones | ASTRAZENECA AB (SE) | 2005-12-08 | — | — | US | disclosed |
| CN-1681763-A | Chemical compounds | ASTRAZENECA AB (SE) | 2005-10-12 | — | — | CN | disclosed |
| EP-1549600-A1 | KETONES | AstraZeneca AB (SE) | 2005-07-06 | — | — | EP | disclosed |
| WO-2004011410-A1 | CHEMICAL COMPOUNDS | ASTRAZENECA AB (SE) | 2004-02-05 | — | — | WO | disclosed |