Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEP1B | Q16820 | 2/20 | 0.57 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.55 |
| ▸ | MEN1 | O00255 | 1/20 | 0.55 |
| ▸ | ACP3 | P15309 | 3/20 | 0.50 |
| ▸ | MDM2 | Q00987 | 1/20 | 0.49 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.48 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.48 |
| ▸ | CES2 | O00748 | 1/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | CES1 | P23141 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.45 |
| ▸ | GABRB1 | P18505 | 2/20 | 0.45 |
| ▸ | GABRB2 | P47870 | 2/20 | 0.45 |
| ▸ | TP53 | P04637 | 1/20 | 0.44 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19248981 | 0.84 | MEN1 (0.59) | MEP1BKMT2AMEN1ACP3SMN1; SMN2 | |
| SCHEMBL27827175 | 0.84 | MEN1 (0.59) | MEP1BKMT2AMEN1ACP3SMN1; SMN2 | |
| SCHEMBL1696017 | 0.84 | MEN1 (0.59) | MEP1BKMT2AMEN1ACP3SMN1; SMN2 | |
| SCHEMBL6321040 | 0.83 | HAT1 (0.54) | — | |
| SCHEMBL6203337 | 0.81 | TDP1 (0.50) | MEP1BKMT2AMEN1MDM2TDP1 | |
| SCHEMBL5178563 | 0.81 | MEN1 (0.56) | MEP1BKMT2AMEN1ACP3SMN1; SMN2 | |
| SCHEMBL8187492 | 0.79 | MEN1 (0.55) | MEP1BKMT2AMEN1ACP3CES2 | |
| SCHEMBL6201593 | 0.79 | ALDH1A1 (0.54) | TDP1L3MBTL1CES2LMNACES1 | |
| SCHEMBL6202507 | 0.78 | SMN1; SMN2 (0.48) | TDP1L3MBTL1CES2LMNACES1 | |
| SCHEMBL8524972 | 0.78 | LMNA (0.50) | MEP1BKMT2AMEN1MDM2TDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20050272036-A1 | Ketones | ASTRAZENECA AB (SE) | 2005-12-08 | — | — | US | disclosed |
| CN-1681763-A | Chemical compounds | ASTRAZENECA AB (SE) | 2005-10-12 | — | — | CN | disclosed |
| EP-1549600-A1 | KETONES | AstraZeneca AB (SE) | 2005-07-06 | — | — | EP | disclosed |
| WO-2004011410-A1 | CHEMICAL COMPOUNDS | ASTRAZENECA AB (SE) | 2004-02-05 | — | — | WO | disclosed |