Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSK | P43235 | 6/20 | 0.43 |
| ▸ | CTSS | P25774 | 5/20 | 0.43 |
| ▸ | CTSL | P07711 | 3/20 | 0.43 |
| ▸ | CTSB | P07858 | 2/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | DPP4 | P27487 | 3/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | CAPN1 | P07384 | 1/20 | 0.37 |
| ▸ | AAK1 | Q2M2I8 | 1/20 | 0.35 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.34 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.34 |
| ▸ | HRH2 | P25021 | 2/20 | 0.34 |
| ▸ | HRH1 | P35367 | 2/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL648657 | 0.92 | CTSK (0.49) | CTSKCTSSCTSLCTSBMAPK1 | |
| SCHEMBL648658 | 0.92 | CTSK (0.49) | CTSKCTSSCTSLCTSBMAPK1 | |
| SCHEMBL27630344 | 0.92 | MAPK1 (0.44) | CTSKCTSSCTSLCTSBMAPK1 | |
| SCHEMBL646244 | 0.92 | MAPK1 (0.44) | CTSKCTSSCTSLCTSBMAPK1 | |
| SCHEMBL6203301 | 0.88 | MAPK1 (0.44) | CTSKCTSSCTSLCTSBMAPK1 | |
| SCHEMBL6203298 | 0.88 | MAPK1 (0.44) | CTSKCTSSCTSLCTSBMAPK1 | |
| SCHEMBL647656 | 0.82 | CTSS (0.46) | CTSKCTSSCTSLCTSBMAPK1 | |
| SCHEMBL27611195 | 0.82 | MAPK1 (0.47) | CTSKCTSSCTSLCTSBMAPK1 | |
| SCHEMBL6761081 | 0.82 | MAPK1 (0.47) | CTSKCTSSCTSLCTSBMAPK1 | |
| SCHEMBL646794 | 0.82 | MAPK1 (0.47) | CTSKCTSSCTSLCTSBMAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1560811-A2 | PHARMACEUTICAL COMPOSITIONS AS INHIBITORS OF DIPEPTIDYL PEPTIDASE-IV (DPP-IV) | Abbott Laboratories (US) | 2005-08-10 | — | — | EP | disclosed |
| WO-2004026822-A2 | PHARMACEUTICAL COMPOSITIONS AS INHIBITORS OF DIPEPTIDYL PEPTIDASE-IV (DPP-IV) | ABBOTT LABORATORIES (US) | 2004-04-01 | — | — | WO | disclosed |