Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CRHR1 | P34998 | 6/20 | 0.45 |
| ▸ | RUNX1 | Q01196 | 1/20 | 0.39 |
| ▸ | CTSA | P10619 | 9/20 | 0.38 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | GCGR | P47871 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6203416 | 0.86 | RUNX1 (0.40) | CRHR1RUNX1CTSASCN9AMEN1 | |
| SCHEMBL5425106 | 0.84 | CRHR1 (0.51) | CRHR1RUNX1CTSASCN9A | |
| SCHEMBL6203918 | 0.80 | CRHR1 (0.48) | CRHR1RUNX1CTSASCN9A | |
| SCHEMBL5409101 | 0.79 | CRHR1 (0.48) | CRHR1RUNX1CTSASCN9AMEN1 | |
| SCHEMBL6204014 | 0.78 | RUNX1 (0.40) | CRHR1RUNX1CTSASCN9AMEN1 | |
| SCHEMBL5404686 | 0.78 | PIM1 (0.46) | CRHR1RUNX1SCN9AMEN1KMT2A | |
| SCHEMBL14416670 | 0.77 | CRHR1 (0.49) | CRHR1RUNX1CTSASCN9A | |
| SCHEMBL6202812 | 0.73 | CRHR1 (0.62) | CRHR1RUNX1CTSA | |
| SCHEMBL5420376 | 0.73 | CRHR1 (0.43) | CRHR1RUNX1SCN9AMEN1KMT2A | |
| SCHEMBL14416669 | 0.69 | CRHR1 (0.52) | CRHR1CTSASCN9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1554258-A1 | 5-SUBSTITUTED-2-ARYLPYRAZINES AS MODULATORS OF CRF RECEPTORS | NEUROGEN CORPORATION (US) | 2005-07-20 | — | — | EP | disclosed |
| WO-2004018437-A1 | 5-SUBSTITUTED-2-ARYLPYRAZINES AS MODULATORS OF CRF RECEPTORS | NEUROGEN CORPORATION (US) | 2004-03-04 | — | — | WO | disclosed |
| EP-1255740-A2 | SUBSTITUTED ARYLPYRAZINES | NEUROGEN CORPORATION (US) | 2002-11-13 | — | — | EP | disclosed |
| WO-2001060806-A2 | SUBSTITUTED ARYLPYRAZINES | NEUROGEN CORPORATION (US) | 2001-08-23 | — | — | WO | disclosed |