Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CRHR1 | P34998 | 14/20 | 0.53 |
| ▸ | TP53 | P04637 | 1/20 | 0.35 |
| ▸ | TLR7 | Q9NYK1 | 3/20 | 0.35 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5432269 | 0.83 | CRHR1 (0.76) | CRHR1 | |
| SCHEMBL7472049 | 0.83 | CRHR1 (0.56) | CRHR1TLR7ADORA3 | |
| SCHEMBL7482544 | 0.82 | CRHR1 (0.52) | CRHR1TLR7 | |
| SCHEMBL7119050 | 0.79 | CRHR1 (0.48) | CRHR1TLR7ADORA3 | |
| SCHEMBL6201263 | 0.79 | CRHR1 (0.62) | CRHR1TLR7 | |
| SCHEMBL6203035 | 0.78 | CRHR1 (0.51) | CRHR1TLR7 | |
| SCHEMBL6202450 | 0.77 | CRHR1 (0.56) | CRHR1TLR7 | |
| SCHEMBL7606978 | 0.77 | CRHR1 (0.59) | CRHR1 | |
| SCHEMBL6203191 | 0.77 | CRHR1 (0.46) | CRHR1TLR7 | |
| SCHEMBL6202690 | 0.77 | CRHR1 (0.46) | CRHR1TLR7ADORA3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1554258-A1 | 5-SUBSTITUTED-2-ARYLPYRAZINES AS MODULATORS OF CRF RECEPTORS | NEUROGEN CORPORATION (US) | 2005-07-20 | — | — | EP | claimed |
| WO-2004018437-A1 | 5-SUBSTITUTED-2-ARYLPYRAZINES AS MODULATORS OF CRF RECEPTORS | NEUROGEN CORPORATION (US) | 2004-03-04 | — | — | WO | claimed |