Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CRHR1 | P34998 | 19/20 | 0.59 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.40 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.40 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7476944 | 0.94 | CRHR1 (0.60) | CRHR1 | |
| SCHEMBL7474786 | 0.92 | CRHR1 (0.63) | CRHR1 | |
| SCHEMBL7477527 | 0.89 | CRHR1 (0.48) | CRHR1 | |
| SCHEMBL7479379 | 0.88 | CRHR1 (0.57) | CRHR1 | |
| SCHEMBL6202370 | 0.87 | CRHR1 (0.51) | CRHR1 | |
| SCHEMBL5525581 | 0.83 | CRHR1 (0.66) | CRHR1 | |
| SCHEMBL6201263 | 0.82 | CRHR1 (0.62) | CRHR1 | |
| SCHEMBL7477918 | 0.82 | CRHR1 (0.70) | CRHR1 | |
| SCHEMBL7472124 | 0.82 | CRHR1 (0.53) | CRHR1 | |
| SCHEMBL7480024 | 0.82 | CRHR1 (0.57) | CRHR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1255740-A2 | SUBSTITUTED ARYLPYRAZINES | NEUROGEN CORPORATION (US) | 2002-11-13 | — | — | EP | claimed |
| WO-2001060806-A2 | SUBSTITUTED ARYLPYRAZINES | NEUROGEN CORPORATION (US) | 2001-08-23 | — | — | WO | claimed |