Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CRHR1 | P34998 | 10/20 | 0.56 |
| ▸ | BRD4 | O60885 | 5/20 | 0.38 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.38 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.38 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | IL1B | P01584 | 2/20 | 0.37 |
| ▸ | TLR7 | Q9NYK1 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5438867 | 0.82 | CRHR1 (0.81) | CRHR1 | |
| SCHEMBL6201263 | 0.82 | CRHR1 (0.62) | CRHR1BRD4TLR7 | |
| SCHEMBL7477663 | 0.80 | CRHR1 (0.45) | CRHR1TLR7 | |
| SCHEMBL4924779 | 0.80 | CRHR1 (0.58) | CRHR1BRD4TLR7 | |
| SCHEMBL6205812 | 0.79 | CRHR1 (0.45) | CRHR1TLR7 | |
| SCHEMBL7472049 | 0.78 | CRHR1 (0.56) | CRHR1TLR7 | |
| SCHEMBL7473622 | 0.78 | CRHR1 (0.58) | CRHR1BRD4TLR7 | |
| SCHEMBL7482570 | 0.78 | CRHR1 (0.57) | CRHR1BRD4 | |
| SCHEMBL6203377 | 0.77 | CRHR1 (0.53) | CRHR1TLR7 | |
| SCHEMBL7484320 | 0.77 | CRHR1 (0.50) | CRHR1TLR7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1554258-A1 | 5-SUBSTITUTED-2-ARYLPYRAZINES AS MODULATORS OF CRF RECEPTORS | NEUROGEN CORPORATION (US) | 2005-07-20 | — | — | EP | claimed |
| WO-2004018437-A1 | 5-SUBSTITUTED-2-ARYLPYRAZINES AS MODULATORS OF CRF RECEPTORS | NEUROGEN CORPORATION (US) | 2004-03-04 | — | — | WO | claimed |