Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR4A2 | P43354 | 2/20 | 0.51 |
| ▸ | NCF1 | P14598 | 1/20 | 0.44 |
| ▸ | SMYD3 | Q9H7B4 | 2/20 | 0.41 |
| ▸ | OPRL1 | P41146 | 1/20 | 0.41 |
| ▸ | SOS2 | Q07890 | 1/20 | 0.40 |
| ▸ | CCNE2 | O96020 | 1/20 | 0.39 |
| ▸ | CDK4 | P11802 | 1/20 | 0.39 |
| ▸ | CCND1 | P24385 | 1/20 | 0.39 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.39 |
| ▸ | CDK2 | P24941 | 1/20 | 0.39 |
| ▸ | LIMK1 | P53667 | 3/20 | 0.38 |
| ▸ | DOT1L | Q8TEK3 | 2/20 | 0.37 |
| ▸ | TERT | O14746 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 2/20 | 0.36 |
| ▸ | BLM | P54132 | 2/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | GNG2 | P59768 | 2/20 | 0.36 |
| ▸ | GNB1 | P62873 | 2/20 | 0.36 |
| ▸ | MMP1 | P03956 | 1/20 | 0.36 |
| ▸ | MMP9 | P14780 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27768402 | 0.75 | KMT2A (0.50) | MEN1KMT2AMAPT | |
| SCHEMBL6201297 | 0.75 | NR4A2 (0.56) | NR4A2NCF1SMYD3SOS2MEN1 | |
| SCHEMBL5356714 | 0.74 | MAP4K4 (0.55) | NR4A2SMYD3OPRL1MEN1KMT2A | |
| SCHEMBL4823097 | 0.71 | NR4A2 (0.66) | NR4A2NCF1SMYD3SOS2MEN1 | |
| SCHEMBL30210360 | 0.71 | NR4A2 (0.66) | NR4A2NCF1SMYD3SOS2MEN1 | |
| SCHEMBL6309385 | 0.71 | NR4A2 (0.51) | NR4A2NCF1SMYD3OPRL1SOS2 | |
| SCHEMBL10133307 | 0.70 | NPC1 (0.61) | MEN1KMT2AALOX15LMNAHSP90AA1 | |
| SCHEMBL28309629 | 0.70 | IP6K1 (0.57) | ALOX15 | |
| Bromide SCHEMBL5989384 | 0.70 | NR4A2 (0.63) | NR4A2NCF1SMYD3SOS2MEN1 | |
| SCHEMBL28321402 | 0.69 | ALDH1A1 (0.44) | CCNE2CDK4CCND1CCNE1CDK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1451156-A4 | 4-AMINOQUINOLINE COMPOUNDS | MERCK & CO INC (US) | 2005-05-25 | — | — | EP | disclosed |
| US-20050009815-A1 | 4-Aminoquinoline compounds | DEVITA ROBERT J (US) | 2005-01-13 | — | — | US | disclosed |
| EP-1451156-A1 | 4-AMINOQUINOLINE COMPOUNDS | Merck & Co., Inc. (US) | 2004-09-01 | — | — | EP | disclosed |
| WO-2003045920-A1 | 4-AMINOQUINOLINE COMPOUNDS | MERCK & CO., INC. (US) | 2003-06-05 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050009815-A1 | 4-Aminoquinoline compounds | MCHR1, MCHR2, MC5R | NR4A2 2037/4885NCF1 4005/4885SMYD3 2633/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.