Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | RECQL | P46063 | 1/20 | 0.39 |
| ▸ | LOX | P28300 | 1/20 | 0.39 |
| ▸ | LOXL3 | P58215 | 1/20 | 0.39 |
| ▸ | LOXL2 | Q9Y4K0 | 1/20 | 0.39 |
| ▸ | ACHE | P22303 | 6/20 | 0.35 |
| ▸ | PTGS2 | P35354 | 6/20 | 0.35 |
| ▸ | BCHE | P06276 | 5/20 | 0.35 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.33 |
| ▸ | AKR1C2 | P52895 | 1/20 | 0.33 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.33 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.32 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.32 |
| ▸ | PFKFB3 | Q16875 | 1/20 | 0.32 |
| ▸ | SMARCA2 | P51531 | 1/20 | 0.31 |
| ▸ | SMARCA4 | P51532 | 1/20 | 0.31 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.31 |
| ▸ | AAK1 | Q2M2I8 | 2/20 | 0.31 |
| ▸ | GRM5 | P41594 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4651277 | 0.79 | RECQL (0.38) | RECQLLOXLOXL3LOXL2TRPA1 | |
| SCHEMBL16011482 | 0.79 | NPC1 (0.40) | NPC1RAB9AACHEPTGS2BCHE | |
| SCHEMBL6206078 | 0.76 | NPC1 (0.39) | NPC1RAB9AACHEPTGS2BCHE | |
| SCHEMBL20096333 | 0.76 | RECQL (0.42) | RECQLLOXLOXL3LOXL2AKR1C3 | |
| SCHEMBL23376898 | 0.74 | RECQL (0.41) | NPC1RAB9ARECQLLOXLOXL3 | |
| SCHEMBL12695310 | 0.74 | RECQL (0.41) | NPC1RAB9ARECQLLOXLOXL3 | |
| SCHEMBL18699316 | 0.74 | RECQL (0.41) | NPC1RAB9ARECQLLOXLOXL3 | |
| SCHEMBL27146027 | 0.74 | RECQL (0.38) | RECQLLOXLOXL3LOXL2AKR1C3 | |
| SCHEMBL2370569 | 0.73 | MMP8 (0.41) | RECQLAKR1C3AKR1C2SMARCA2SMARCA4 | |
| SCHEMBL6204290 | 0.73 | NPC1 (0.37) | NPC1RAB9AACHEPTGS2BCHE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-107820494-A | Nuclear receptor modulators | 艾伯维公司 | 2018-03-20 | — | — | CN | disclosed |
| EP-1551841-A1 | PYRAZOLOPYRIMIDINES AS KINASE INHIBITORS | SmithKline Beecham Corporation (US) | 2005-07-13 | — | — | EP | disclosed |
| WO-2004009602-A1 | PYRAZOLOPYRIMIDINES AS KINASE INHIBITORS | SMITHKLINE BEECHAM CORPORATION (US) | 2004-01-29 | — | — | WO | disclosed |
| EP-0282077-B1 | Pyridyloxy derivatives | FUJIREBIO KK (JP) | 1993-11-10 | — | — | EP | disclosed |
| US-4977267-A | ANTISECRETORY AGENT | FUJIREBIO KABUSHIKI KAISHA (JP) | 1990-12-11 | — | — | US | disclosed |
| US-4912101-A | Containing a secondary amide, suflur group and a furan ring | FUJIREBIO KABUSHIKI KAISHA (JP) | 1990-03-27 | — | — | US | disclosed |
| EP-0282077-A2 | Pyridyloxy derivatives | FUJIREBIO KABUSHIKI KAISHA (JP) | 1988-09-14 | — | — | EP | disclosed |