Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 2/20 | 0.39 |
| ▸ | RAB9A | P51151 | 2/20 | 0.39 |
| ▸ | BCHE | P06276 | 5/20 | 0.33 |
| ▸ | ACHE | P22303 | 5/20 | 0.33 |
| ▸ | PTGS2 | P35354 | 5/20 | 0.33 |
| ▸ | MITF | O75030 | 1/20 | 0.33 |
| ▸ | PKM | P14618 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6203415 | 0.76 | NPC1 (0.40) | NPC1RAB9ABCHEACHEPTGS2 | |
| SCHEMBL16011482 | 0.76 | NPC1 (0.40) | NPC1RAB9ABCHEACHEPTGS2 | |
| SCHEMBL3258617 | 0.75 | SLC6A4 (0.49) | — | |
| SCHEMBL19773692 | 0.74 | ALDH1A1 (0.35) | NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL29200664 | 0.72 | ROCK1 (0.34) | — | |
| SCHEMBL17000204 | 0.72 | — | — | |
| SCHEMBL6204290 | 0.71 | NPC1 (0.37) | NPC1RAB9ABCHEACHEPTGS2 | |
| SCHEMBL623356 | 0.70 | PTGS2 (0.44) | NPC1RAB9ABCHEACHEPTGS2 | |
| SCHEMBL13180194 | 0.67 | NOS3 (0.53) | RAB9APKML3MBTL1 | |
| SCHEMBL6394314 | 0.66 | PTGS2 (0.57) | NPC1RAB9ABCHEACHEPTGS2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1551841-A1 | PYRAZOLOPYRIMIDINES AS KINASE INHIBITORS | SmithKline Beecham Corporation (US) | 2005-07-13 | — | — | EP | disclosed |
| WO-2004009602-A1 | PYRAZOLOPYRIMIDINES AS KINASE INHIBITORS | SMITHKLINE BEECHAM CORPORATION (US) | 2004-01-29 | — | — | WO | disclosed |
| WO-2004009602-A1 | PYRAZOLOPYRIMIDINES AS KINASE INHIBITORS | SMITHKLINE BEECHAM CORPORATION (US) | 2004-01-29 | — | — | WO | disclosed |