Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 3/20 | 0.60 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.60 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.55 |
| ▸ | SIRT1 | Q96EB6 | 2/20 | 0.53 |
| ▸ | HSD17B10 | Q99714 | 5/20 | 0.53 |
| ▸ | HPGD | P15428 | 5/20 | 0.53 |
| ▸ | TP53 | P04637 | 4/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.53 |
| ▸ | NPC1 | O15118 | 2/20 | 0.53 |
| ▸ | RAB9A | P51151 | 2/20 | 0.53 |
| ▸ | LMNA | P02545 | 2/20 | 0.53 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.53 |
| ▸ | MEN1 | O00255 | 2/20 | 0.53 |
| ▸ | USP2 | O75604 | 1/20 | 0.53 |
| ▸ | TSHR | P16473 | 1/20 | 0.53 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.53 |
| ▸ | FAAH | O00519 | 1/20 | 0.50 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.49 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6086068 | 0.83 | MAPT (0.53) | GAASMN1; SMN2KDM4EHSD17B10HPGD | |
| SCHEMBL6203914 | 0.82 | KDM4E (0.52) | GAASMN1; SMN2KDM4ESIRT1HSD17B10 | |
| SCHEMBL6201149 | 0.81 | GAA (0.54) | GAASMN1; SMN2KDM4ESIRT1HSD17B10 | |
| SCHEMBL6085377 | 0.81 | MAPT (0.47) | GAASMN1; SMN2KDM4EHSD17B10HPGD | |
| SCHEMBL6203549 | 0.80 | SMN1; SMN2 (0.52) | GAASMN1; SMN2KDM4ESIRT1HSD17B10 | |
| SCHEMBL6202061 | 0.79 | FAAH (0.58) | GAASMN1; SMN2KDM4ESIRT1HSD17B10 | |
| SCHEMBL6085893 | 0.78 | MAPT (0.51) | GAASMN1; SMN2KDM4EHSD17B10HPGD | |
| SCHEMBL6084151 | 0.77 | MAPT (0.61) | GAASMN1; SMN2KDM4EHSD17B10HPGD | |
| SCHEMBL6203082 | 0.76 | HSD17B10 (0.56) | GAASMN1; SMN2KDM4EHSD17B10HPGD | |
| SCHEMBL6203041 | 0.76 | FAAH (0.50) | GAASMN1; SMN2KDM4ESIRT1HSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1377589-B1 | OXAZOLYL-PYRAZOLE DERIVATIVES AS KINASE INHIBITORS | PHARMACIA ITALIA SPA (IT) | 2005-09-07 | — | — | EP | claimed |