Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 2/20 | 0.54 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.54 |
| ▸ | MAPT | P10636 | 7/20 | 0.53 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.53 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.53 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.53 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.53 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.53 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.53 |
| ▸ | SIRT1 | Q96EB6 | 2/20 | 0.51 |
| ▸ | TP53 | P04637 | 5/20 | 0.50 |
| ▸ | HPGD | P15428 | 3/20 | 0.50 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.50 |
| ▸ | NPC1 | O15118 | 2/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.50 |
| ▸ | LMNA | P02545 | 2/20 | 0.50 |
| ▸ | RAB9A | P51151 | 2/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.50 |
| ▸ | POLB | P06746 | 1/20 | 0.50 |
| ▸ | MEN1 | O00255 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6203431 | 0.81 | GAA (0.60) | GAASMN1; SMN2MAPTKDM4ECYP1A2 | |
| SCHEMBL6203549 | 0.79 | SMN1; SMN2 (0.52) | GAASMN1; SMN2MAPTKDM4ECYP1A2 | |
| SCHEMBL6203914 | 0.78 | KDM4E (0.52) | GAASMN1; SMN2MAPTKDM4ECYP1A2 | |
| SCHEMBL6086300 | 0.78 | CEPT1 (0.47) | MAPTKDM4ETP53HPGDALDH1A1 | |
| SCHEMBL6202061 | 0.77 | FAAH (0.58) | GAASMN1; SMN2MAPTKDM4ECYP1A2 | |
| SCHEMBL6085369 | 0.76 | MAPT (0.48) | SMN1; SMN2MAPTKDM4ETP53HPGD | |
| SCHEMBL6084969 | 0.74 | LMNA (0.64) | SMN1; SMN2MAPTKDM4ETP53ALDH1A1 | |
| SCHEMBL6203082 | 0.74 | HSD17B10 (0.56) | GAASMN1; SMN2MAPTKDM4ECYP1A2 | |
| SCHEMBL6203041 | 0.74 | FAAH (0.50) | GAASMN1; SMN2MAPTKDM4ECYP1A2 | |
| SCHEMBL14614666 | 0.73 | SMN1; SMN2 (0.75) | GAASMN1; SMN2MAPTKDM4ECYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1377589-B1 | OXAZOLYL-PYRAZOLE DERIVATIVES AS KINASE INHIBITORS | PHARMACIA ITALIA SPA (IT) | 2005-09-07 | — | — | EP | claimed |