Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.55 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.55 |
| ▸ | LMNA | P02545 | 5/20 | 0.53 |
| ▸ | CES2 | O00748 | 1/20 | 0.53 |
| ▸ | CES1 | P23141 | 1/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.49 |
| ▸ | HTT | P42858 | 1/20 | 0.49 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.49 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.47 |
| ▸ | TSHR | P16473 | 2/20 | 0.47 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.47 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.47 |
| ▸ | RGS12 | O14924 | 1/20 | 0.47 |
| ▸ | GLA | P06280 | 1/20 | 0.47 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.47 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.47 |
| ▸ | PKM | P14618 | 1/20 | 0.47 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.47 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.47 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1712339 | 0.81 | CYP2D6 (0.50) | TDP1LMNAALDH1A1CYP3A4HSD17B10 | |
| SCHEMBL1964866 | 0.81 | CYP2D6 (0.50) | TDP1LMNAALDH1A1CYP3A4HSD17B10 | |
| SCHEMBL5225847 | 0.81 | CYP2D6 (0.50) | TDP1LMNAALDH1A1CYP3A4HSD17B10 | |
| SCHEMBL5505755 | 0.81 | TDP1 (0.52) | TDP1L3MBTL1LMNACES2CES1 | |
| SCHEMBL77141 | 0.81 | TDP1 (0.52) | TDP1L3MBTL1LMNACES2CES1 | |
| SCHEMBL23861285 | 0.80 | TDP1 (0.55) | TDP1L3MBTL1LMNACES2CES1 | |
| SCHEMBL13052942 | 0.80 | TDP1 (0.55) | TDP1L3MBTL1LMNACES2CES1 | |
| SCHEMBL28457962 | 0.80 | TDP1 (0.55) | TDP1L3MBTL1LMNACES2CES1 | |
| SCHEMBL6203337 | 0.79 | TDP1 (0.50) | TDP1L3MBTL1LMNACES2CES1 | |
| SCHEMBL6966020 | 0.79 | KMT2A (0.45) | TDP1LMNAALDH1A1CYP3A4HSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20050272036-A1 | Ketones | ASTRAZENECA AB (SE) | 2005-12-08 | — | — | US | disclosed |
| CN-1681763-A | Chemical compounds | ASTRAZENECA AB (SE) | 2005-10-12 | — | — | CN | disclosed |
| EP-1549600-A1 | KETONES | AstraZeneca AB (SE) | 2005-07-06 | — | — | EP | disclosed |
| WO-2004011410-A1 | CHEMICAL COMPOUNDS | ASTRAZENECA AB (SE) | 2004-02-05 | — | — | WO | disclosed |
| EP-0098911-B1 | IMPROVED PROCESS FOR THE PREPARATION OF OXIMATOHYDRIDOSILANES AND AMINOXYHYDRIDOSILANES | UNION CARBIDE CORPORATION (US) | 1986-04-16 | — | — | EP | disclosed |