Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | IDO1 | P14902 | 2/20 | 0.42 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.42 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.41 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.41 |
| ▸ | HTT | P42858 | 2/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 2/20 | 0.40 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.40 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.40 |
| ▸ | ATM | Q13315 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.39 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.39 |
| ▸ | HTR7 | P34969 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9480529 | 0.84 | IDO1 (0.52) | ALDH1A1IDO1TAAR1CHRM2CHRM1 | |
| SCHEMBL6201896 | 0.79 | IDO1 (0.38) | ALDH1A1IDO1TAAR1CYP2D6CYP3A4 | |
| SCHEMBL6202381 | 0.79 | SLC6A2 (0.41) | ALDH1A1IDO1TAAR1GAAMAPT | |
| SCHEMBL6204860 | 0.74 | TSHR (0.47) | ALDH1A1TAAR1TSHRCYP1A2SLC6A2 | |
| SCHEMBL6206375 | 0.74 | IDO1 (0.48) | ALDH1A1IDO1TAAR1CHRM2CHRM1 | |
| SCHEMBL28805376 | 0.73 | IDO1 (0.52) | ALDH1A1IDO1TAAR1CHRM2CHRM1 | |
| SCHEMBL29364891 | 0.73 | IDO1 (0.62) | ALDH1A1IDO1TAAR1CHRM2CHRM1 | |
| SCHEMBL585111 | 0.73 | IDO1 (0.62) | ALDH1A1IDO1TAAR1CHRM2CHRM1 | |
| SCHEMBL7442131 | 0.73 | IDO1 (0.47) | ALDH1A1IDO1TAAR1CHRM2CHRM1 | |
| SCHEMBL9479313 | 0.73 | IDO1 (0.47) | ALDH1A1IDO1TAAR1CHRM2CHRM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1506175-A1 | N-SUBSTITUTED TRICYCLIC 3-AMINOPYRAZOLES AS PDGF RECEPTOR INHIBITORS | JANSSEN PHARMACEUTICA N.V. (BE) | 2005-02-16 | — | — | EP | disclosed |
| WO-2003097609-A1 | N-SUBSTITUTED TRICYCLIC 3-AMINOPYRAZOLES AS PDFG RECEPTOR INHIBITORS | JANSSEN PHARMACEUTICA N.V. (BE) | 2003-11-27 | — | — | WO | disclosed |