Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A2 | P23975 | 1/20 | 0.41 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.41 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.41 |
| ▸ | PPARG | P37231 | 1/20 | 0.39 |
| ▸ | PPARA | Q07869 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.39 |
| ▸ | IDO1 | P14902 | 3/20 | 0.38 |
| ▸ | PNMT | P11086 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 3/20 | 0.36 |
| ▸ | DAO | P14920 | 1/20 | 0.36 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | TAAR1 | Q96RJ0 | 2/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.35 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6204299 | 0.81 | KDM4E (0.44) | ALDH1A1KMT2ATAAR1MAPTCYP1A2 | |
| SCHEMBL6201896 | 0.80 | IDO1 (0.38) | SLC6A2SLC6A4SLC6A3PPARGPPARA | |
| SCHEMBL9480317 | 0.80 | IDO1 (0.50) | SLC6A2SLC6A4SLC6A3PPARGPPARA | |
| SCHEMBL6203702 | 0.79 | ALDH1A1 (0.42) | SLC6A2SLC6A4SLC6A3ALDH1A1IDO1 | |
| SCHEMBL6204860 | 0.75 | TSHR (0.47) | SLC6A2SLC6A4SLC6A3ALDH1A1TAAR1 | |
| SCHEMBL6507641 | 0.72 | IDO1 (0.57) | SLC6A2SLC6A4SLC6A3ALDH1A1IDO1 | |
| SCHEMBL21726735 | 0.72 | IDO1 (0.46) | SLC6A2SLC6A4SLC6A3PPARGPPARA | |
| SCHEMBL6205165 | 0.72 | PPARG (0.43) | SLC6A2SLC6A4SLC6A3PPARGPPARA | |
| SCHEMBL2673394 | 0.70 | ALDH1A1 (0.50) | PPARGPPARAALDH1A1LMNAEPHX2 | |
| SCHEMBL6680412 | 0.69 | ALDH1A1 (0.44) | SLC6A2SLC6A4SLC6A3PPARGPPARA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1506175-A1 | N-SUBSTITUTED TRICYCLIC 3-AMINOPYRAZOLES AS PDGF RECEPTOR INHIBITORS | JANSSEN PHARMACEUTICA N.V. (BE) | 2005-02-16 | — | — | EP | disclosed |
| WO-2003097609-A1 | N-SUBSTITUTED TRICYCLIC 3-AMINOPYRAZOLES AS PDFG RECEPTOR INHIBITORS | JANSSEN PHARMACEUTICA N.V. (BE) | 2003-11-27 | — | — | WO | disclosed |