Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PHGDH | O43175 | 1/20 | 0.48 |
| ▸ | CD274 | Q9NZQ7 | 1/20 | 0.47 |
| ▸ | PKM | P14618 | 1/20 | 0.47 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | TP53 | P04637 | 1/20 | 0.46 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | USP2 | O75604 | 1/20 | 0.44 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6203436 | 0.87 | ATM (0.46) | MAPTMEN1KMT2AALDH1A1USP2 | |
| SCHEMBL12576431 | 0.86 | POLB (0.50) | HSD11B1MAPTMEN1KMT2ATP53 | |
| SCHEMBL6325994 | 0.79 | RAD52 (0.46) | PKMHSD11B1ALDH1A1SMN1; SMN2L3MBTL1 | |
| SCHEMBL6319724 | 0.77 | HTR2A (0.46) | PHGDHHSD11B1ALDH1A1 | |
| SCHEMBL1266219 | 0.77 | HSD11B1 (0.54) | HSD11B1MAPTMEN1KMT2AALDH1A1 | |
| SCHEMBL10368830 | 0.75 | ATM (0.61) | PHGDHCD274MAPTMEN1KMT2A | |
| SCHEMBL14452149 | 0.74 | MEN1 (0.58) | MEN1KMT2AALDH1A1SMN1; SMN2 | |
| SCHEMBL941270 | 0.74 | PARP10 (0.54) | HSD11B1KMT2A | |
| SCHEMBL12123771 | 0.73 | ALDH1A1 (0.73) | CD274MAPTKMT2ATP53ALDH1A1 | |
| Hydrochloric Acid SCHEMBL7929073 | 0.72 | ALDH1A1 (0.74) | MAPTKMT2ATP53ALDH1A1L3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20050272036-A1 | Ketones | ASTRAZENECA AB (SE) | 2005-12-08 | — | — | US | claimed |
| EP-1549600-A1 | KETONES | AstraZeneca AB (SE) | 2005-07-06 | — | — | EP | claimed |
| WO-2004011410-A1 | CHEMICAL COMPOUNDS | ASTRAZENECA AB (SE) | 2004-02-05 | — | — | WO | claimed |
| US-20050272036-A1 | Ketones | ASTRAZENECA AB (SE) | 2005-12-08 | — | — | US | disclosed |
| EP-1549600-A1 | KETONES | AstraZeneca AB (SE) | 2005-07-06 | — | — | EP | disclosed |
| WO-2004011410-A1 | CHEMICAL COMPOUNDS | ASTRAZENECA AB (SE) | 2004-02-05 | — | — | WO | disclosed |