Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ATM | Q13315 | 1/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.44 |
| ▸ | GSK3B | P49841 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 3/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.41 |
| ▸ | MAPT | P10636 | 3/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | PRKDC | P78527 | 1/20 | 0.41 |
| ▸ | MPI | P34949 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | USP2 | O75604 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6203754 | 0.87 | PHGDH (0.48) | MAPK1L3MBTL1KMT2AMEN1ALDH1A1 | |
| SCHEMBL932621 | 0.74 | ATM (0.57) | ATMMAPK1GSK3BLMNAKMT2A | |
| SCHEMBL12576431 | 0.72 | POLB (0.50) | MAPK1KMT2AMEN1ALDH1A1MAPT | |
| SCHEMBL5510141 | 0.71 | HPGD (0.49) | MAPK1L3MBTL1LMNAKMT2AMEN1 | |
| SCHEMBL1199899 | 0.71 | CA12 (0.48) | L3MBTL1LMNAALDH1A1GAAKDM4E | |
| SCHEMBL2923158 | 0.70 | POLB (0.73) | MAPK1L3MBTL1LMNAKMT2AMEN1 | |
| SCHEMBL25490049 | 0.70 | HPGD (0.56) | MAPK1L3MBTL1KMT2AALDH1A1MAPT | |
| SCHEMBL4264406 | 0.70 | KDM4E (0.48) | L3MBTL1LMNAALDH1A1GAAKDM4E | |
| SCHEMBL28701120 | 0.69 | NPC1 (0.54) | L3MBTL1LMNAALDH1A1MAPTGAA | |
| SCHEMBL6326207 | 0.69 | ALDH1A1 (0.59) | KMT2AMEN1ALDH1A1MAPTGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20050272036-A1 | Ketones | ASTRAZENECA AB (SE) | 2005-12-08 | — | — | US | claimed |
| EP-1549600-A1 | KETONES | AstraZeneca AB (SE) | 2005-07-06 | — | — | EP | claimed |
| WO-2004011410-A1 | CHEMICAL COMPOUNDS | ASTRAZENECA AB (SE) | 2004-02-05 | — | — | WO | claimed |
| US-20050272036-A1 | Ketones | ASTRAZENECA AB (SE) | 2005-12-08 | — | — | US | disclosed |
| EP-1549600-A1 | KETONES | AstraZeneca AB (SE) | 2005-07-06 | — | — | EP | disclosed |
| WO-2004011410-A1 | CHEMICAL COMPOUNDS | ASTRAZENECA AB (SE) | 2004-02-05 | — | — | WO | disclosed |