SCHEMBL6203796

SCHEMBL6203796

COC(O)c1c(F)cc(F)cc1F

nearest known ligand 0.32

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
CES2 O00748 2/20 0.32
CES1 P23141 2/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL20644237 0.78 KDM4E (0.33)
SCHEMBL6204097 0.77 CES2 (0.44) CES2CES1
SCHEMBL10705429 0.77 CES2 (0.47) CES2CES1
SCHEMBL6204939 0.74 CES2 (0.42) CES2CES1
SCHEMBL24944411 0.74 ALDH1A1 (0.30)
SCHEMBL23212715 0.73 MEN1 (0.41) CES2CES1
SCHEMBL1994643 0.73 MEN1 (0.41) CES2CES1
SCHEMBL6203793 0.73 CES2 (0.31) CES2CES1
SCHEMBL22909980 0.72 CES2 (0.47) CES2CES1
SCHEMBL2093717 0.72 CES2 (0.37) CES2CES1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1506175-A1 N-SUBSTITUTED TRICYCLIC 3-AMINOPYRAZOLES AS PDGF RECEPTOR INHIBITORS JANSSEN PHARMACEUTICA N.V. (BE) 2005-02-16 EP disclosed
WO-2003097609-A1 N-SUBSTITUTED TRICYCLIC 3-AMINOPYRAZOLES AS PDFG RECEPTOR INHIBITORS JANSSEN PHARMACEUTICA N.V. (BE) 2003-11-27 WO disclosed