Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 10/20 | 0.72 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.58 |
| ▸ | DPP7 | Q9UHL4 | 1/20 | 0.54 |
| ▸ | GAA | P10253 | 1/20 | 0.50 |
| ▸ | MAPT | P10636 | 1/20 | 0.50 |
| ▸ | NPC1 | O15118 | 1/20 | 0.49 |
| ▸ | HTT | P42858 | 1/20 | 0.49 |
| ▸ | RAB9A | P51151 | 1/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.49 |
| ▸ | LTA4H | P09960 | 1/20 | 0.49 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.47 |
| ▸ | DRD3 | P35462 | 1/20 | 0.46 |
| ▸ | ACHE | P22303 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14938163 | 0.98 | SIGMAR1 (0.70) | SIGMAR1SLC6A3DPP7GAAMAPT | |
| SCHEMBL7402412 | 0.84 | SIGMAR1 (0.58) | SIGMAR1GAAMAPTHTTSMN1; SMN2 | |
| SCHEMBL9019137 | 0.84 | SIGMAR1 (1.00) | SIGMAR1SLC6A3DPP7LTA4HDRD3 | |
| SCHEMBL8797435 | 0.81 | DPP7 (0.68) | SIGMAR1SLC6A3DPP7GAAMAPT | |
| Hydrochloric Acid SCHEMBL5756391 | 0.81 | SIGMAR1 (0.93) | SIGMAR1SLC6A3DPP7GAAMAPT | |
| SCHEMBL9866577 | 0.80 | SIGMAR1 (0.79) | SIGMAR1SLC6A3DPP7LTA4H | |
| SCHEMBL111527 | 0.79 | DPP7 (0.66) | SIGMAR1SLC6A3DPP7LTA4HACHE | |
| SCHEMBL6223815 | 0.78 | MCHR1 (0.68) | SIGMAR1SLC6A3DPP7GAAMAPT | |
| Hydrochloric Acid SCHEMBL8843424 | 0.78 | DPP7 (0.64) | SIGMAR1SLC6A3DPP7GAAMAPT | |
| SCHEMBL11725246 | 0.77 | SIGMAR1 (0.60) | SIGMAR1SLC6A3DPP7HTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20050272036-A1 | Ketones | ASTRAZENECA AB (SE) | 2005-12-08 | — | — | US | disclosed |
| EP-1549600-A1 | KETONES | AstraZeneca AB (SE) | 2005-07-06 | — | — | EP | disclosed |
| WO-2004011410-A1 | CHEMICAL COMPOUNDS | ASTRAZENECA AB (SE) | 2004-02-05 | — | — | WO | disclosed |