Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A4 | P31645 | 16/20 | 0.42 |
| ▸ | SLC6A2 | P23975 | 15/20 | 0.42 |
| ▸ | SLC6A3 | Q01959 | 8/20 | 0.42 |
| ▸ | KCNH2 | Q12809 | 6/20 | 0.38 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.37 |
| ▸ | HTR6 | P50406 | 1/20 | 0.37 |
| ▸ | CCR8 | P51685 | 1/20 | 0.36 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6204695 | 0.94 | SLC6A2 (0.40) | SLC6A4SLC6A2SLC6A3KCNH2CYP2D6 | |
| SCHEMBL6204001 | 0.91 | SLC6A4 (0.39) | SLC6A4SLC6A2SLC6A3KCNH2CYP2D6 | |
| SCHEMBL6416674 | 0.88 | CYP1A2 (0.43) | SLC6A4SLC6A2SLC6A3KCNH2CYP2D6 | |
| SCHEMBL6204231 | 0.85 | CCR8 (0.51) | CCR8 | |
| SCHEMBL6256044 | 0.84 | HTR2A (0.46) | SLC6A4SLC6A2SLC6A3KCNH2HTR6 | |
| SCHEMBL6411940 | 0.80 | CCR8 (0.59) | CCR8 | |
| SCHEMBL6415241 | 0.79 | CCR8 (0.55) | CCR8 | |
| SCHEMBL6203108 | 0.79 | CCR8 (0.47) | CCR8 | |
| SCHEMBL6203974 | 0.78 | SLC6A2 (0.42) | SLC6A4SLC6A2SLC6A3KCNH2HTR6 | |
| SCHEMBL6248463 | 0.78 | CCR8 (0.46) | CCR8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1590327-A1 | CCR8 INHIBITORS | MILLENNIUM PHARMACEUTICALS, INC. (US) | 2005-11-02 | — | — | EP | disclosed |
| EP-1581511-A1 | CCR8 INHIBITORS | MILLENNIUM PHARMACEUTICALS, INC. (US) | 2005-10-05 | — | — | EP | disclosed |
| WO-2004058709-A1 | CCR8 INHIBITORS | MILLENNIUM PHARMACEUTICALS, INC. (US) | 2004-07-15 | — | — | WO | disclosed |
| WO-2004058736-A1 | CCR8 INHIBITORS | MILLENNIUM PHARMACEUTICALS, INC. (US) | 2004-07-15 | — | — | WO | disclosed |