Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRD4 | O60885 | 1/20 | 0.50 |
| ▸ | CACNA2D1 | P54289 | 2/20 | 0.44 |
| ▸ | CACNA1B | Q00975 | 2/20 | 0.44 |
| ▸ | CACNB1 | Q02641 | 2/20 | 0.44 |
| ▸ | CACNA1C | Q13936 | 2/20 | 0.44 |
| ▸ | CACNA1G | O43497 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 2/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.42 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.42 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.42 |
| ▸ | ATM | Q13315 | 1/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 3/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | TACR1 | P25103 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11527977 | 0.88 | LMNA (0.53) | BRD4CACNA2D1CACNA1BCACNB1CACNA1C | |
| SCHEMBL6429187 | 0.82 | KEAP1 (0.40) | BRD4LMNASLC6A2SLC6A4SLC6A3 | |
| SCHEMBL225075 | 0.79 | SLC6A2 (0.38) | BRD4CACNA2D1CACNA1BCACNB1CACNA1C | |
| 3,3-Diphenylpropanoic Acid SCHEMBL8965643 | 0.77 | BRD4 (0.51) | BRD4CACNA2D1CACNA1BCACNB1CACNA1C | |
| SCHEMBL11895218 | 0.76 | FFAR1 (0.55) | LMNAPOLBL3MBTL1MEN1KMT2A | |
| SCHEMBL18823101 | 0.75 | L3MBTL1 (0.52) | BRD4LMNAPOLBSLC6A2SLC6A4 | |
| SCHEMBL14781389 | 0.75 | SRC (0.47) | BRD4LMNASLC6A2SLC6A4SLC6A3 | |
| SCHEMBL19041261 | 0.75 | LMNA (0.66) | LMNAL3MBTL1MEN1KMT2ATDP1 | |
| SCHEMBL11532202 | 0.75 | KMT2A (0.56) | BRD4LMNAPOLBATMMEN1 | |
| SCHEMBL11526990 | 0.74 | CYP2D6 (0.49) | LMNASLC6A2SLC6A4SLC6A3MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20050272036-A1 | Ketones | ASTRAZENECA AB (SE) | 2005-12-08 | — | — | US | disclosed |
| EP-1549600-A1 | KETONES | AstraZeneca AB (SE) | 2005-07-06 | — | — | EP | disclosed |
| WO-2004011410-A1 | CHEMICAL COMPOUNDS | ASTRAZENECA AB (SE) | 2004-02-05 | — | — | WO | disclosed |