Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KEAP1 | Q14145 | 2/20 | 0.67 |
| ▸ | NFE2L2 | Q16236 | 2/20 | 0.67 |
| ▸ | RECQL | P46063 | 1/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.55 |
| ▸ | MAPT | P10636 | 1/20 | 0.55 |
| ▸ | PPARG | P37231 | 1/20 | 0.54 |
| ▸ | PTGES | O14684 | 3/20 | 0.54 |
| ▸ | ALOX5 | P09917 | 2/20 | 0.54 |
| ▸ | CA12 | O43570 | 1/20 | 0.53 |
| ▸ | CA9 | Q16790 | 1/20 | 0.53 |
| ▸ | CNR1 | P21554 | 1/20 | 0.52 |
| ▸ | CNR2 | P34972 | 1/20 | 0.52 |
| ▸ | MEN1 | O00255 | 2/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.52 |
| ▸ | ESR1 | P03372 | 1/20 | 0.51 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.51 |
| ▸ | OXTR | P30559 | 1/20 | 0.51 |
| ▸ | AVPR1A | P37288 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL699184 | 0.87 | KEAP1 (0.88) | KEAP1NFE2L2KMT2APPARGCA12 | |
| SCHEMBL28561073 | 0.84 | KEAP1 (0.61) | KEAP1NFE2L2KMT2AMAPTPPARG | |
| SCHEMBL6204172 | 0.84 | ESR1 (0.55) | KEAP1NFE2L2RECQLKMT2AMAPT | |
| SCHEMBL14145796 | 0.84 | RECQL (0.60) | KEAP1NFE2L2RECQLKMT2APTGES | |
| SCHEMBL11603483 | 0.82 | RECQL (0.59) | KEAP1NFE2L2RECQLKMT2ACA12 | |
| SCHEMBL5568657 | 0.82 | NR1I2 (0.65) | KEAP1NFE2L2KMT2APPARGMEN1 | |
| SCHEMBL28575718 | 0.82 | KEAP1 (0.61) | KEAP1NFE2L2KMT2AMAPTPPARG | |
| SCHEMBL14502622 | 0.79 | KEAP1 (0.66) | KEAP1NFE2L2KMT2AMAPTPPARG | |
| SCHEMBL28564469 | 0.79 | LMNA (0.54) | KEAP1NFE2L2KMT2AMAPTPPARG | |
| SCHEMBL5604160 | 0.79 | ESR1 (0.73) | KEAP1NFE2L2KMT2AMAPTCA12 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20050272036-A1 | Ketones | ASTRAZENECA AB (SE) | 2005-12-08 | — | — | US | disclosed |
| EP-1549600-A1 | KETONES | AstraZeneca AB (SE) | 2005-07-06 | — | — | EP | disclosed |
| WO-2004011410-A1 | CHEMICAL COMPOUNDS | ASTRAZENECA AB (SE) | 2004-02-05 | — | — | WO | disclosed |