Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 2/20 | 0.48 |
| ▸ | GAA | P10253 | 1/20 | 0.48 |
| ▸ | RAB9A | P51151 | 1/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.31 |
| ▸ | P2RX4 | Q99571 | 1/20 | 0.31 |
| ▸ | MAOA | P21397 | 1/20 | 0.31 |
| ▸ | MAOB | P27338 | 1/20 | 0.31 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.31 |
| ▸ | FER | P16591 | 1/20 | 0.31 |
| ▸ | LTK | P29376 | 1/20 | 0.31 |
| ▸ | CDK8 | P49336 | 1/20 | 0.31 |
| ▸ | ACVR1 | Q04771 | 1/20 | 0.31 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.31 |
| ▸ | DYRK1B | Q9Y463 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6204410 | 1.00 | MAPT (0.48) | MAPTGAARAB9ASMN1; SMN2P2RX4 | |
| SCHEMBL7440282 | 0.72 | MAPT (0.56) | MAPTGAARAB9ASMN1; SMN2P2RX4 | |
| SCHEMBL7440281 | 0.72 | MAPT (0.56) | MAPTGAARAB9ASMN1; SMN2P2RX4 | |
| SCHEMBL4787144 | 0.69 | MAPT (0.50) | MAPTGAAMAOAMAOBPDGFRA | |
| SCHEMBL124177 | 0.69 | MAPT (0.50) | MAPTGAAMAOAMAOBPDGFRA | |
| SCHEMBL3632795 | 0.68 | GAA (0.44) | MAPTGAA | |
| Iminostilbene SCHEMBL29926907 | 0.67 | MAPT (1.00) | MAPTGAARAB9ASMN1; SMN2P2RX4 | |
| Iminostilbene SCHEMBL75288 | 0.67 | MAPT (1.00) | MAPTGAARAB9ASMN1; SMN2P2RX4 | |
| SCHEMBL5816758 | 0.66 | MAPT (0.47) | MAPTGAARAB9ASMN1; SMN2P2RX4 | |
| SCHEMBL5816754 | 0.66 | MAPT (0.47) | MAPTGAARAB9ASMN1; SMN2P2RX4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1497296-A1 | 1,4 DIAZOCINO 7,8,1-hi INDOLE DERIVATIVES AS ANTIPSYCHOTIC AND ANTIOBESITY AGENTS | Wyeth (US) | 2005-01-19 | — | — | EP | disclosed |
| WO-2003091257-A1 | [1,4]DIAZOCINO [7,8,1-hi]INDOLE DERIVATIVES AS ANTIPSYCHOTIC AND ANTIOBESITY AGENTS | WYETH (US) | 2003-11-06 | — | — | WO | disclosed |