Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CRHR1 | P34998 | 17/20 | 0.42 |
| ▸ | SOAT1 | P35610 | 1/20 | 0.32 |
| ▸ | FAAH | O00519 | 1/20 | 0.31 |
| ▸ | MGLL | Q99685 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6203742 | 0.99 | CRHR1 (0.42) | CRHR1 | |
| SCHEMBL6200455 | 0.87 | CRHR1 (0.41) | CRHR1 | |
| SCHEMBL6203669 | 0.83 | CRHR1 (0.56) | CRHR1SOAT1 | |
| SCHEMBL5438838 | 0.80 | CRHR1 (0.57) | CRHR1 | |
| SCHEMBL6203954 | 0.80 | CRHR1 (0.44) | CRHR1 | |
| SCHEMBL6202927 | 0.79 | CRHR1 (0.45) | CRHR1 | |
| SCHEMBL6203029 | 0.79 | CRHR1 (0.46) | CRHR1 | |
| SCHEMBL7475717 | 0.75 | CRHR1 (0.60) | CRHR1 | |
| SCHEMBL6201091 | 0.74 | CRHR1 (0.43) | CRHR1 | |
| SCHEMBL7478531 | 0.74 | TLR8 (0.44) | CRHR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1554258-A1 | 5-SUBSTITUTED-2-ARYLPYRAZINES AS MODULATORS OF CRF RECEPTORS | NEUROGEN CORPORATION (US) | 2005-07-20 | — | — | EP | claimed |
| WO-2004018437-A1 | 5-SUBSTITUTED-2-ARYLPYRAZINES AS MODULATORS OF CRF RECEPTORS | NEUROGEN CORPORATION (US) | 2004-03-04 | — | — | WO | claimed |