Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CRHR1 | P34998 | 19/20 | 0.42 |
| ▸ | CYP2C8 | P10632 | 1/20 | 0.31 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.31 |
| ▸ | CYP2B6 | P20813 | 1/20 | 0.31 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.31 |
| ▸ | FLT3 | P36888 | 1/20 | 0.31 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.31 |
| ▸ | HASPIN | Q8TF76 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6204414 | 0.99 | CRHR1 (0.42) | CRHR1 | |
| SCHEMBL6200455 | 0.88 | CRHR1 (0.41) | CRHR1 | |
| SCHEMBL6203669 | 0.84 | CRHR1 (0.56) | CRHR1 | |
| SCHEMBL5438838 | 0.81 | CRHR1 (0.57) | CRHR1 | |
| SCHEMBL6201986 | 0.81 | CRHR1 (0.39) | CRHR1 | |
| SCHEMBL6203029 | 0.80 | CRHR1 (0.46) | CRHR1 | |
| SCHEMBL6202927 | 0.80 | CRHR1 (0.45) | CRHR1 | |
| SCHEMBL5433561 | 0.80 | CRHR1 (0.50) | CRHR1 | |
| SCHEMBL6203563 | 0.79 | CRHR1 (0.44) | CRHR1 | |
| SCHEMBL6203954 | 0.79 | CRHR1 (0.44) | CRHR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1554258-A1 | 5-SUBSTITUTED-2-ARYLPYRAZINES AS MODULATORS OF CRF RECEPTORS | NEUROGEN CORPORATION (US) | 2005-07-20 | — | — | EP | claimed |
| WO-2004018437-A1 | 5-SUBSTITUTED-2-ARYLPYRAZINES AS MODULATORS OF CRF RECEPTORS | NEUROGEN CORPORATION (US) | 2004-03-04 | — | — | WO | claimed |