Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CRHR1 | P34998 | 10/20 | 0.56 |
| ▸ | PLAU | P00749 | 1/20 | 0.34 |
| ▸ | SOAT1 | P35610 | 1/20 | 0.34 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.34 |
| ▸ | BRD9 | Q9H8M2 | 1/20 | 0.33 |
| ▸ | BRD7 | Q9NPI1 | 1/20 | 0.33 |
| ▸ | CASR | P41180 | 2/20 | 0.33 |
| ▸ | APOBEC3A | P31941 | 1/20 | 0.32 |
| ▸ | APOBEC3G | Q9HC16 | 1/20 | 0.32 |
| ▸ | POLB | P06746 | 1/20 | 0.32 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6203742 | 0.84 | CRHR1 (0.42) | CRHR1 | |
| SCHEMBL6201986 | 0.83 | CRHR1 (0.39) | CRHR1 | |
| SCHEMBL6204414 | 0.83 | CRHR1 (0.42) | CRHR1SOAT1 | |
| SCHEMBL6199707 | 0.81 | CRHR1 (0.57) | CRHR1PLAUBRD9BRD7 | |
| SCHEMBL5441186 | 0.79 | CRHR1 (0.63) | CRHR1PLAUBRD9BRD7 | |
| SCHEMBL6204988 | 0.78 | CRHR1 (0.60) | CRHR1 | |
| SCHEMBL7478531 | 0.78 | TLR8 (0.44) | CRHR1 | |
| SCHEMBL6201091 | 0.78 | CRHR1 (0.43) | CRHR1 | |
| SCHEMBL5434595 | 0.78 | CRHR1 (0.59) | CRHR1PLAUBRD9BRD7 | |
| SCHEMBL7482386 | 0.77 | CRHR1 (0.42) | CRHR1PDE10A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1554258-A1 | 5-SUBSTITUTED-2-ARYLPYRAZINES AS MODULATORS OF CRF RECEPTORS | NEUROGEN CORPORATION (US) | 2005-07-20 | — | — | EP | claimed |
| WO-2004018437-A1 | 5-SUBSTITUTED-2-ARYLPYRAZINES AS MODULATORS OF CRF RECEPTORS | NEUROGEN CORPORATION (US) | 2004-03-04 | — | — | WO | claimed |