Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | F2 | P00734 | 3/20 | 0.54 |
| ▸ | F10 | P00742 | 2/20 | 0.54 |
| ▸ | F12 | P00748 | 1/20 | 0.54 |
| ▸ | F7 | P08709 | 1/20 | 0.54 |
| ▸ | F3 | P13726 | 1/20 | 0.54 |
| ▸ | PKM | P14618 | 1/20 | 0.54 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.53 |
| ▸ | PRMT1 | Q99873 | 1/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.53 |
| ▸ | HPGD | P15428 | 1/20 | 0.53 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.53 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.53 |
| ▸ | BLM | P54132 | 1/20 | 0.52 |
| ▸ | WDR5 | P61964 | 1/20 | 0.52 |
| ▸ | PRSS1 | P07477 | 4/20 | 0.50 |
| ▸ | PRSS2 | P07478 | 4/20 | 0.50 |
| ▸ | PRSS3 | P35030 | 4/20 | 0.50 |
| ▸ | C1S | P09871 | 2/20 | 0.50 |
| ▸ | RECQL | P46063 | 1/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6180083 | 0.93 | F2 (0.54) | F2F10F12F7F3 | |
| SCHEMBL1468321 | 0.90 | PRMT5 (0.59) | F2F10PRMT5PRMT1ALDH1A1 | |
| SCHEMBL69726 | 0.77 | MAOB (0.57) | ALDH1A1HPGDHSD17B10LOXL2 | |
| SCHEMBL28457429 | 0.76 | LMNA (0.59) | ALDH1A1HPGDHSD17B10KMT2A | |
| SCHEMBL2528043 | 0.76 | TAAR1 (0.50) | PKMALDH1A1CYP2C19BLMRECQL | |
| SCHEMBL428473 | 0.76 | PRMT1 (0.83) | F2F10F12F7F3 | |
| SCHEMBL8366101 | 0.76 | MAOB (0.52) | PKMALDH1A1CYP2C19HSD17B10KMT2A | |
| SCHEMBL428474 | 0.76 | PRMT1 (0.83) | F2F10F12F7F3 | |
| SCHEMBL27680541 | 0.76 | PRSS1 (0.69) | F2F10F12F7F3 | |
| SCHEMBL6207335 | 0.76 | PRMT5 (0.61) | F2F10F12F7F3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1539762-A2 | BICYCLIC PYRIMIDINONES AS COAGULATION CASCADE INHIBITORS | Bristol-Myers Squibb Company (US) | 2005-06-15 | — | — | EP | disclosed |
| WO-2004002406-A2 | BICYCLIC PYRIMIDINONES AS COAGULATION CASCADE INHIBITORS | BRISTOL-MYERS SQUIBB COMPANY (US) | 2004-01-08 | — | — | WO | disclosed |