Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FDFT1 | P37268 | 2/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | NQO2 | P16083 | 1/20 | 0.43 |
| ▸ | NAMPT | P43490 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | IDO1 | P14902 | 1/20 | 0.42 |
| ▸ | MGLL | Q99685 | 1/20 | 0.41 |
| ▸ | AKT1 | P31749 | 1/20 | 0.41 |
| ▸ | GLS | O94925 | 1/20 | 0.41 |
| ▸ | PLAAT3 | P53816 | 1/20 | 0.40 |
| ▸ | PLAAT5 | Q96KN8 | 1/20 | 0.40 |
| ▸ | PLAAT2 | Q9NWW9 | 1/20 | 0.40 |
| ▸ | PLAAT4 | Q9UL19 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6202190 | 0.88 | PLAAT3 (0.48) | FDFT1POLBNQO2NAMPTKDM4E | |
| SCHEMBL6202759 | 0.87 | PLAAT3 (0.52) | POLBNQO2KDM4EPLAAT3PLAAT5 | |
| SCHEMBL5354570 | 0.85 | FDFT1 (0.57) | FDFT1NQO2NAMPTIDO1PLAAT3 | |
| SCHEMBL6203942 | 0.83 | FDFT1 (0.47) | FDFT1POLBNQO2NAMPTKDM4E | |
| SCHEMBL21090366 | 0.82 | FDFT1 (0.47) | FDFT1POLBNQO2NAMPTKDM4E | |
| SCHEMBL31506266 | 0.81 | CYP2D6 (0.58) | NQO2KDM4EIDO1 | |
| SCHEMBL67569 | 0.81 | CYP2D6 (0.58) | NQO2KDM4EIDO1 | |
| SCHEMBL6204579 | 0.80 | MTNR1A (0.58) | POLB | |
| SCHEMBL21090363 | 0.78 | CYP4F2 (0.49) | FDFT1NQO2 | |
| SCHEMBL3026698 | 0.77 | CYP2D6 (0.58) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1581498-A2 | PYRIDINYL, PYRIMIDINYL AND PYRAZINYL AMIDES AS POTASSIUM CHANNEL OPENERS | Bristol-Myers Squibb Company (US) | 2005-10-05 | — | — | EP | disclosed |
| WO-2004047739-A2 | PYRIDINYL, PYRIMIDINYL AND PYRAZINYL AMIDES AS POTASSIUM CHANNEL OPENERS | BRISTOL-MYERS SQUIBB COMPANY (US) | 2004-06-10 | — | — | WO | disclosed |