Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TAS1R3 | Q7RTX0 | 2/20 | 0.56 |
| ▸ | TAS1R1 | Q7RTX1 | 2/20 | 0.56 |
| ▸ | NPC1 | O15118 | 3/20 | 0.53 |
| ▸ | HPGD | P15428 | 2/20 | 0.53 |
| ▸ | RAB9A | P51151 | 2/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.53 |
| ▸ | LMNA | P02545 | 1/20 | 0.51 |
| ▸ | HTT | P42858 | 1/20 | 0.51 |
| ▸ | MAPT | P10636 | 2/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.50 |
| ▸ | TAS2R14 | Q9NYV8 | 1/20 | 0.50 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.49 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.49 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.49 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.49 |
| ▸ | GRM1 | Q13255 | 1/20 | 0.48 |
| ▸ | PLAU | P00749 | 1/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.48 |
| ▸ | SRD5A2 | P31213 | 2/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL257535 | 0.88 | NPC1 (0.53) | NPC1HPGDRAB9ASMN1; SMN2LMNA | |
| SCHEMBL1515747 | 0.88 | NPC1 (0.63) | NPC1HPGDRAB9ASMN1; SMN2LMNA | |
| SCHEMBL6575456 | 0.85 | GAA (0.56) | NPC1HPGDRAB9ASMN1; SMN2LMNA | |
| SCHEMBL1515704 | 0.84 | HTT (0.62) | TAS1R3TAS1R1NPC1HPGDRAB9A | |
| SCHEMBL29236861 | 0.84 | LMNA (0.54) | TAS1R3TAS1R1NPC1SMN1; SMN2LMNA | |
| SCHEMBL7220907 | 0.84 | MAPT (0.55) | TAS1R3TAS1R1NPC1HPGDRAB9A | |
| SCHEMBL14982198 | 0.83 | NPC1 (0.60) | TAS1R3TAS1R1NPC1HPGDRAB9A | |
| SCHEMBL7040136 | 0.82 | CES2 (0.58) | NPC1RAB9ASMN1; SMN2LMNAMAPT | |
| SCHEMBL6060544 | 0.82 | HTT (0.61) | NPC1HPGDRAB9ASMN1; SMN2HTT | |
| SCHEMBL7047105 | 0.81 | SMN1; SMN2 (0.80) | NPC1HPGDRAB9ASMN1; SMN2MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20050272036-A1 | Ketones | ASTRAZENECA AB (SE) | 2005-12-08 | — | — | US | disclosed |
| EP-1549600-A1 | KETONES | AstraZeneca AB (SE) | 2005-07-06 | — | — | EP | disclosed |
| WO-2004011410-A1 | CHEMICAL COMPOUNDS | ASTRAZENECA AB (SE) | 2004-02-05 | — | — | WO | disclosed |