Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 3/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.47 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.45 |
| ▸ | PDGFRB | P09619 | 2/20 | 0.44 |
| ▸ | PDGFRA | P16234 | 2/20 | 0.44 |
| ▸ | FLT3 | P36888 | 2/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.43 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | FPR2 | P25090 | 4/20 | 0.42 |
| ▸ | DRD2 | P14416 | 2/20 | 0.42 |
| ▸ | DRD3 | P35462 | 2/20 | 0.42 |
| ▸ | ADH1A | P07327 | 1/20 | 0.41 |
| ▸ | KIT | P10721 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6517364 | 0.90 | ADH1A (0.53) | MEN1KMT2AHRH4PDGFRBPDGFRA | |
| SCHEMBL6517359 | 0.90 | ADH1A (0.53) | MEN1KMT2AHRH4PDGFRBPDGFRA | |
| SCHEMBL2399027 | 0.89 | MEN1 (0.49) | MEN1KMT2AHRH4PDGFRBPDGFRA | |
| SCHEMBL8107146 | 0.88 | ADH1A (0.45) | MEN1KMT2AHRH4AKR1C3NPC1 | |
| SCHEMBL8113421 | 0.88 | PDGFRB (0.51) | MEN1KMT2APDGFRBPDGFRAFLT3 | |
| SCHEMBL6206250 | 0.87 | MEN1 (0.44) | MEN1KMT2AHRH4PDGFRBPDGFRA | |
| SCHEMBL7672527 | 0.86 | MEN1 (0.47) | MEN1KMT2AHRH4PDGFRBPDGFRA | |
| SCHEMBL6207384 | 0.85 | HDAC2 (0.44) | MEN1KMT2AKDM4ENPC1RAB9A | |
| SCHEMBL5864982 | 0.84 | DRD2 (0.44) | MEN1KMT2AHRH4PDGFRBPDGFRA | |
| SCHEMBL18269960 | 0.84 | AKR1C3 (0.41) | MEN1KMT2AHRH4PDGFRBPDGFRA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0938474-B1 | CYCLOPROPYLINDOLE COMPOUNDS AND THEIR USE AS PRODRUGS | AUCKLAND UNISERVICES LTD (NZ) | 2005-11-23 | — | — | EP | disclosed |
| US-6130237-A | Condensed N-aclyindoles as antitumor agents | CANCER RESEARCH CAMPAIGN TECHNOLOGY LIMITED (GB) | 2000-10-10 | — | — | US | disclosed |