Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC2 | Q92769 | 2/20 | 0.44 |
| ▸ | ADH1A | P07327 | 1/20 | 0.42 |
| ▸ | KIT | P10721 | 1/20 | 0.42 |
| ▸ | FLT1 | P17948 | 1/20 | 0.42 |
| ▸ | FLT4 | P35916 | 1/20 | 0.42 |
| ▸ | KDR | P35968 | 1/20 | 0.42 |
| ▸ | ABL2 | P42684 | 1/20 | 0.42 |
| ▸ | MMP13 | P45452 | 2/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.38 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.38 |
| ▸ | PYGL | P06737 | 2/20 | 0.35 |
| ▸ | F11 | P03951 | 2/20 | 0.34 |
| ▸ | MAOA | P21397 | 1/20 | 0.34 |
| ▸ | NPC1 | O15118 | 2/20 | 0.34 |
| ▸ | RAB9A | P51151 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.34 |
| ▸ | SYK | P43405 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL436370 | 0.92 | MMP13 (0.46) | HDAC2ADH1AKITFLT1FLT4 | |
| SCHEMBL6517367 | 0.92 | ADH1A (0.52) | HDAC2ADH1AKITFLT1FLT4 | |
| SCHEMBL6517373 | 0.92 | ADH1A (0.52) | HDAC2ADH1AKITFLT1FLT4 | |
| SCHEMBL10111775 | 0.88 | MMP13 (0.42) | HDAC2ADH1AKITFLT1FLT4 | |
| SCHEMBL469094 | 0.88 | MMP13 (0.42) | HDAC2ADH1AKITFLT1FLT4 | |
| SCHEMBL6204957 | 0.87 | ADH1A (0.40) | HDAC2ADH1AKITFLT1FLT4 | |
| SCHEMBL8107146 | 0.87 | ADH1A (0.45) | HDAC2ADH1AKITFLT1FLT4 | |
| SCHEMBL16151965 | 0.86 | MMP13 (0.41) | HDAC2ADH1AKITFLT1FLT4 | |
| SCHEMBL13498776 | 0.86 | NPC1 (0.41) | ADH1AKITFLT1FLT4KDR | |
| SCHEMBL13800023 | 0.86 | ADH1A (0.47) | HDAC2ADH1AKITFLT1FLT4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0938474-B1 | CYCLOPROPYLINDOLE COMPOUNDS AND THEIR USE AS PRODRUGS | AUCKLAND UNISERVICES LTD (NZ) | 2005-11-23 | — | — | EP | disclosed |
| US-6130237-A | Condensed N-aclyindoles as antitumor agents | CANCER RESEARCH CAMPAIGN TECHNOLOGY LIMITED (GB) | 2000-10-10 | — | — | US | disclosed |