Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 3/20 | 0.39 |
| ▸ | CRHR1 | P34998 | 5/20 | 0.37 |
| ▸ | TLR7 | Q9NYK1 | 4/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | PGK1 | P00558 | 4/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.34 |
| ▸ | HPGD | P15428 | 2/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.34 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.34 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.34 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.34 |
| ▸ | TLR8 | Q9NR97 | 1/20 | 0.33 |
| ▸ | GSK3B | P49841 | 1/20 | 0.33 |
| ▸ | MAP4K2 | Q12851 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7476643 | 0.84 | CRHR1 (0.44) | POLBCRHR1TLR7ALDH1A1TLR8 | |
| SCHEMBL6201012 | 0.83 | TLR7 (0.41) | POLBCRHR1TLR7ALDH1A1TLR8 | |
| SCHEMBL6203447 | 0.81 | TLR7 (0.38) | POLBCRHR1TLR7ALDH1A1PGK1 | |
| SCHEMBL5449186 | 0.81 | CRHR1 (0.48) | CRHR1 | |
| SCHEMBL6204586 | 0.76 | USP8 (0.43) | POLBCRHR1TLR7ALDH1A1SMN1; SMN2 | |
| SCHEMBL6203800 | 0.74 | CRHR1 (0.39) | POLBCRHR1TLR7ALDH1A1KDM4E | |
| SCHEMBL6200464 | 0.73 | TLR7 (0.42) | POLBCRHR1TLR7ALDH1A1CYP2C9 | |
| SCHEMBL6201435 | 0.72 | CRHR1 (0.41) | POLBCRHR1TLR7ALDH1A1TLR8 | |
| SCHEMBL6203100 | 0.72 | CRHR1 (0.40) | CRHR1TLR7TLR8 | |
| SCHEMBL6199780 | 0.72 | CRHR1 (0.40) | POLBCRHR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1554258-A1 | 5-SUBSTITUTED-2-ARYLPYRAZINES AS MODULATORS OF CRF RECEPTORS | NEUROGEN CORPORATION (US) | 2005-07-20 | — | — | EP | claimed |
| WO-2004018437-A1 | 5-SUBSTITUTED-2-ARYLPYRAZINES AS MODULATORS OF CRF RECEPTORS | NEUROGEN CORPORATION (US) | 2004-03-04 | — | — | WO | claimed |