Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | USP8 | P40818 | 2/20 | 0.43 |
| ▸ | CRHR1 | P34998 | 2/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | HPGD | P15428 | 2/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | TLR7 | Q9NYK1 | 3/20 | 0.35 |
| ▸ | CFTR | P13569 | 1/20 | 0.35 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | ACHE | P22303 | 4/20 | 0.34 |
| ▸ | BCHE | P06276 | 3/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5635197 | 0.82 | CRHR1 (0.60) | USP8CRHR1 | |
| SCHEMBL6203800 | 0.80 | CRHR1 (0.39) | USP8CRHR1POLBALDH1A1HPGD | |
| SCHEMBL7477663 | 0.77 | CRHR1 (0.45) | CRHR1ALDH1A1HPGDTLR7ACHE | |
| SCHEMBL7478779 | 0.76 | CRHR1 (0.44) | CRHR1ALDH1A1KDM4ELMNACYP1A2 | |
| SCHEMBL6204612 | 0.76 | POLB (0.39) | CRHR1POLBALDH1A1HPGDKDM4E | |
| SCHEMBL7119050 | 0.75 | CRHR1 (0.48) | CRHR1TLR7 | |
| SCHEMBL6199780 | 0.74 | CRHR1 (0.40) | CRHR1POLBALOX15 | |
| SCHEMBL6203191 | 0.71 | CRHR1 (0.46) | CRHR1POLBALDH1A1HPGDKDM4E | |
| SCHEMBL6202690 | 0.71 | CRHR1 (0.46) | CRHR1ALDH1A1LMNATLR7 | |
| SCHEMBL5634047 | 0.71 | CRHR1 (0.60) | USP8CRHR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1554258-A1 | 5-SUBSTITUTED-2-ARYLPYRAZINES AS MODULATORS OF CRF RECEPTORS | NEUROGEN CORPORATION (US) | 2005-07-20 | — | — | EP | claimed |
| WO-2004018437-A1 | 5-SUBSTITUTED-2-ARYLPYRAZINES AS MODULATORS OF CRF RECEPTORS | NEUROGEN CORPORATION (US) | 2004-03-04 | — | — | WO | claimed |