Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RXRA | P19793 | 1/20 | 0.44 |
| ▸ | RXRB | P28702 | 1/20 | 0.44 |
| ▸ | ACHE | P22303 | 4/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.42 |
| ▸ | MEN1 | O00255 | 2/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
| ▸ | AOC3 | Q16853 | 2/20 | 0.41 |
| ▸ | BCHE | P06276 | 3/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | NSD2 | O96028 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | FAAH | O00519 | 1/20 | 0.39 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.39 |
| ▸ | PTPN5 | P54829 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | MARK4 | Q96L34 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6055421 | 0.83 | RXRA (0.47) | RXRARXRBACHEL3MBTL1PTGS1 | |
| SCHEMBL6202883 | 0.83 | AOC3 (0.56) | ACHEL3MBTL1AOC3ALDH1A1 | |
| SCHEMBL6055201 | 0.81 | RXRA (0.46) | RXRARXRBACHEL3MBTL1PTGS1 | |
| SCHEMBL2737262 | 0.79 | KDM4E (0.49) | RXRARXRBACHEPTGS1KMT2A | |
| SCHEMBL6204636 | 0.79 | RXRA (0.44) | RXRARXRBACHEL3MBTL1PTGS1 | |
| SCHEMBL16937842 | 0.78 | L3MBTL1 (0.50) | RXRARXRBACHEL3MBTL1HTT | |
| SCHEMBL1417003 | 0.77 | RXRA (0.43) | RXRARXRBACHEL3MBTL1PTGS1 | |
| SCHEMBL6204184 | 0.77 | TP53 (0.49) | RXRARXRBL3MBTL1AOC3ALDH1A1 | |
| SCHEMBL6055487 | 0.77 | LMNA (0.50) | RXRARXRBACHEL3MBTL1HTT | |
| SCHEMBL6396089 | 0.77 | PTGS1 (0.53) | RXRARXRBACHEPTGS1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1506175-A1 | N-SUBSTITUTED TRICYCLIC 3-AMINOPYRAZOLES AS PDGF RECEPTOR INHIBITORS | JANSSEN PHARMACEUTICA N.V. (BE) | 2005-02-16 | — | — | EP | disclosed |
| WO-2003097609-A1 | N-SUBSTITUTED TRICYCLIC 3-AMINOPYRAZOLES AS PDFG RECEPTOR INHIBITORS | JANSSEN PHARMACEUTICA N.V. (BE) | 2003-11-27 | — | — | WO | disclosed |