Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AOC3 | Q16853 | 1/20 | 0.50 |
| ▸ | ACP3 | P15309 | 1/20 | 0.43 |
| ▸ | PDE1B | Q01064 | 2/20 | 0.41 |
| ▸ | HSD17B2 | P37059 | 1/20 | 0.41 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.40 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.40 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.40 |
| ▸ | CASR | P41180 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6203322 | 0.79 | AOC3 (0.53) | AOC3ACP3PDE1BHSD17B2SLC6A2 | |
| SCHEMBL6205144 | 0.79 | TSHR (0.38) | AOC3ALDH1A1MEN1KMT2A | |
| SCHEMBL11395224 | 0.78 | AOC3 (0.51) | AOC3ACP3PDE1BHSD17B2SLC6A2 | |
| SCHEMBL3096347 | 0.78 | AOC3 (0.56) | AOC3ACP3PDE1BHSD17B2SLC6A2 | |
| SCHEMBL6205041 | 0.78 | IDO1 (0.46) | ALDH1A1MEN1KMT2A | |
| SCHEMBL5168017 | 0.78 | AOC3 (0.49) | AOC3ACP3ALDH1A1 | |
| SCHEMBL1047528 | 0.77 | ACP3 (0.47) | AOC3ACP3ALDH1A1MEN1KMT2A | |
| SCHEMBL2601111 | 0.76 | PNMT (0.47) | AOC3ACP3PDE1BSLC6A2SLC6A4 | |
| SCHEMBL6204068 | 0.76 | AOC3 (0.50) | AOC3 | |
| SCHEMBL6202881 | 0.76 | AOC3 (0.50) | AOC3CASRALDH1A1MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1668601-A | N-substituted tricyclic 3-aminopyrazoles as PDFG receptor inhibitors | JANSSEN PHARMACEUTICA NV (BE) | 2005-09-14 | — | — | CN | disclosed |
| EP-1506175-A1 | N-SUBSTITUTED TRICYCLIC 3-AMINOPYRAZOLES AS PDGF RECEPTOR INHIBITORS | JANSSEN PHARMACEUTICA N.V. (BE) | 2005-02-16 | — | — | EP | disclosed |
| WO-2003097609-A1 | N-SUBSTITUTED TRICYCLIC 3-AMINOPYRAZOLES AS PDFG RECEPTOR INHIBITORS | JANSSEN PHARMACEUTICA N.V. (BE) | 2003-11-27 | — | — | WO | disclosed |