Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CASR | P41180 | 3/20 | 0.47 |
| ▸ | AOC3 | Q16853 | 3/20 | 0.46 |
| ▸ | ACHE | P22303 | 1/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.45 |
| ▸ | TAAR1 | Q96RJ0 | 2/20 | 0.44 |
| ▸ | CA1 | P00915 | 1/20 | 0.44 |
| ▸ | CA2 | P00918 | 1/20 | 0.44 |
| ▸ | CA7 | P43166 | 1/20 | 0.44 |
| ▸ | CA9 | Q16790 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29671559 | 0.85 | AOC3 (0.49) | CASRAOC3ACHEL3MBTL1TAAR1 | |
| SCHEMBL6204381 | 0.82 | AOC3 (0.53) | CASRAOC3ACHEL3MBTL1TAAR1 | |
| SCHEMBL14060408 | 0.80 | CASR (0.50) | CASRAOC3ACHEL3MBTL1TAAR1 | |
| SCHEMBL5990929 | 0.80 | CASR (0.50) | CASRAOC3ACHEL3MBTL1TAAR1 | |
| SCHEMBL10290007 | 0.79 | CASR (0.53) | CASRAOC3ACHEL3MBTL1TAAR1 | |
| SCHEMBL30601580 | 0.79 | HDAC4 (0.55) | CASRAOC3ACHEL3MBTL1TAAR1 | |
| SCHEMBL84440 | 0.79 | HDAC4 (0.55) | CASRAOC3ACHEL3MBTL1TAAR1 | |
| SCHEMBL11619720 | 0.79 | CASR (0.53) | CASRAOC3ACHEL3MBTL1TAAR1 | |
| SCHEMBL11965250 | 0.78 | CASR (0.49) | CASRAOC3ACHEL3MBTL1TAAR1 | |
| SCHEMBL10446047 | 0.78 | AOC3 (0.53) | CASRAOC3ACHEL3MBTL1TAAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1506175-A1 | N-SUBSTITUTED TRICYCLIC 3-AMINOPYRAZOLES AS PDGF RECEPTOR INHIBITORS | JANSSEN PHARMACEUTICA N.V. (BE) | 2005-02-16 | — | — | EP | disclosed |
| WO-2003097609-A1 | N-SUBSTITUTED TRICYCLIC 3-AMINOPYRAZOLES AS PDFG RECEPTOR INHIBITORS | JANSSEN PHARMACEUTICA N.V. (BE) | 2003-11-27 | — | — | WO | disclosed |