SCHEMBL84440

SCHEMBL84440

COc1cccc(C(C)C)c1

nearest known ligand 0.56

Predicted protein targets (top 15)

geneUniProtsupporting neighboursconfidence
HDAC4 P56524 1/20 0.55
HDAC8 Q9BY41 1/20 0.55
CASR P41180 3/20 0.53
ACHE P22303 1/20 0.52
AOC3 Q16853 3/20 0.51
TAAR1 Q96RJ0 2/20 0.50
L3MBTL1 Q9Y468 1/20 0.50
CA1 P00915 1/20 0.50
CA2 P00918 1/20 0.50
CA7 P43166 1/20 0.50
CA9 Q16790 1/20 0.50
KDM4E B2RXH2 1/20 0.50
TSHR P16473 1/20 0.50
ALDH1A1 P00352 1/20 0.50
CYP3A4 P08684 1/20 0.50

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL30601580 1.00 HDAC4 (0.55) HDAC4HDAC8CASRACHEAOC3
SCHEMBL26378345 0.92 SMN1; SMN2 (0.59) HDAC4HDAC8CASRACHEAOC3
SCHEMBL487170 0.88 CYP1A1 (0.53) HDAC4HDAC8CASRACHETAAR1
SCHEMBL10290007 0.86 CASR (0.53) CASRACHEAOC3TAAR1L3MBTL1
SCHEMBL11619720 0.86 CASR (0.53) CASRACHEAOC3TAAR1L3MBTL1
SCHEMBL14020499 0.86 SMN1; SMN2 (0.58) HDAC4HDAC8CASRKDM4ETSHR
SCHEMBL12545715 0.85 KDM4E (0.46) HDAC4HDAC8CASRAOC3TAAR1
SCHEMBL10446047 0.84 AOC3 (0.53) CASRACHEAOC3TAAR1L3MBTL1
SCHEMBL15271036 0.84 CASR (0.51) CASRACHEAOC3TAAR1L3MBTL1
SCHEMBL30345552 0.84 PTGS1 (0.56) HDAC4HDAC8CA1CA2CA9

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1560 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-115368218-B Method for preparing 4-diaryl methyl substituted phenol compound 湖南理工学院 2024-01-02 CN claimed
CN-115368218-A Method for preparing 4-diaryl methyl substituted phenol compound 湖南理工学院 2022-11-22 CN claimed
US-8426115-B2 Patterning process and resist composition SHIN-ETSU CHEMICAL CO., LTD. (JP) 2013-04-23 US claimed
US-20110033803-A1 PATTERNING PROCESS AND RESIST COMPOSITION SHIN-ETSU CHEMICAL CO., LTD. (JP) 2011-02-10 US claimed
US-20100159392-A1 PATTERNING PROCESS AND RESIST COMPOSITION SHIN-ETSU CHEMICAL CO., LTD. (JP) 2010-06-24 US claimed
US-4473713-A Hydrolysis of aryl-aliphatic ethers RHONE-POULENC SPECIALITES CHIMIQUES (FR) 1984-09-25 US claimed
US-12043613-B2 Inhibitors of SARM1 DISARM THERAPEUTICS, INC. (US) 2024-07-23 US disclosed
US-12043613-B2 Inhibitors of SARM1 DISARM THERAPEUTICS, INC. (US) 2024-07-23 US disclosed
EP-3365334-B1 BENZOLACTAM COMPOUNDS AS PROTEIN KINASE INHIBITORS OTSUKA PHARMA CO LTD (JP) 2024-07-17 EP disclosed
US-12037323-B2 Uracil derivatives as Mer-AXL inhibitors BRISTOL-MYERS SQUIBB COMPANY (US) 2024-07-16 US disclosed
US-12037323-B2 Uracil derivatives as Mer-AXL inhibitors BRISTOL-MYERS SQUIBB COMPANY (US) 2024-07-16 US disclosed
WO-2024148060-A1 MK2 DEGRADERS AND USES THEREOF KYMERA THERAPEUTICS, INC. (US) 2024-07-11 WO disclosed
US-12030876-B2 Aryl hydrocarbon receptor (AHR) agonists and uses thereof Ikena Oncology, Inc. (US) 2024-07-09 US disclosed
WO-1997011930-A1 AROMATIC COMPOUND ACYLATION METHOD RHODIA CHIMIE (FR) 1997-04-03 WO disclosed
WO-1996037452-A1 METHOD FOR HYDROXYALKYLATING A CARBOCYCLIC AROMATIC ETHER RHONE-POULENC CHIMIE (FR) 1996-11-28 WO disclosed
WO-1996035656-A1 AROMATIC ETHER ACYLATION PROCESS RHONE-POULENC CHIMIE (FR) 1996-11-14 WO disclosed
EP-0698593-A1 Process for the acylation of an aromatic compound RHONE-POULENC CHIMIE (FR) 1996-02-28 EP disclosed
US-4837301-A FROM ALKALI MTEAL SULFIDES AND AROMATIC DIHALOGEN COMPOUNDS; IMPROVED CORROSION RESISTANCE BAYER AKTIENGESELLSCHAFT (DE) 1989-06-06 US disclosed
EP-0275007-A2 Process for the preparation of highly molecular, optionally branched polyarylene sulfides BAYER AG (DE) 1988-07-20 EP disclosed
US-4473713-A Hydrolysis of aryl-aliphatic ethers RHONE-POULENC SPECIALITES CHIMIQUES (FR) 1984-09-25 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-12037323-B2 Uracil derivatives as Mer-AXL inhibitors MERTK, DAPK1, AXL HDAC4 3365/4885HDAC8 2511/4885CASR 2390/4885
US-12030876-B2 Aryl hydrocarbon receptor (AHR) agonists and uses thereof AHR, ARNT, HCAR1 HDAC4 1486/4885HDAC8 1169/4885CASR 589/4885
US-12043613-B2 Inhibitors of SARM1 SARM1, SMN1; SMN2, SARNP HDAC4 1812/4885HDAC8 859/4885CASR 3975/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.