Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CES2 | O00748 | 1/20 | 0.44 |
| ▸ | CES1 | P23141 | 1/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.44 |
| ▸ | MEN1 | O00255 | 4/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.41 |
| ▸ | IDO1 | P14902 | 2/20 | 0.40 |
| ▸ | TDO2 | P48775 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.39 |
| ▸ | LMNA | P02545 | 2/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.38 |
| ▸ | MC4R | P32245 | 1/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.36 |
| ▸ | PKM | P14618 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18892781 | 0.84 | GABRA1 (0.39) | CYP3A4KMT2AALDH1A1LMNACYP2C9 | |
| SCHEMBL20386379 | 0.80 | CES2 (0.34) | CES2CES1CYP3A4MEN1KMT2A | |
| SCHEMBL25663412 | 0.80 | CES2 (0.34) | CES2CES1CYP3A4MEN1KMT2A | |
| SCHEMBL15087394 | 0.78 | GAA (0.46) | CES2CES1CYP3A4MEN1KMT2A | |
| SCHEMBL9019981 | 0.77 | IDO1 (0.42) | CES2CES1CYP3A4MEN1KMT2A | |
| SCHEMBL11602791 | 0.76 | CES2 (0.54) | CES2CES1CYP3A4MEN1KMT2A | |
| SCHEMBL6204702 | 0.76 | GABRA1 (0.48) | CYP3A4KMT2ALMNA | |
| SCHEMBL1755231 | 0.76 | ESR1 (0.52) | CYP3A4ALDH1A1LMNACYP2C9GAA | |
| SCHEMBL6203758 | 0.76 | CA1 (0.52) | CYP3A4IDO1TDO2ALDH1A1LMNA | |
| SCHEMBL467714 | 0.76 | GABRA1 (0.54) | CYP3A4ALDH1A1LMNAMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1506175-A1 | N-SUBSTITUTED TRICYCLIC 3-AMINOPYRAZOLES AS PDGF RECEPTOR INHIBITORS | JANSSEN PHARMACEUTICA N.V. (BE) | 2005-02-16 | — | — | EP | disclosed |
| WO-2003097609-A1 | N-SUBSTITUTED TRICYCLIC 3-AMINOPYRAZOLES AS PDFG RECEPTOR INHIBITORS | JANSSEN PHARMACEUTICA N.V. (BE) | 2003-11-27 | — | — | WO | disclosed |