Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR35 | Q9HC97 | 3/20 | 0.43 |
| ▸ | BCL2L1 | Q07817 | 1/20 | 0.40 |
| ▸ | PLK4 | O00444 | 2/20 | 0.38 |
| ▸ | AURKA | O14965 | 2/20 | 0.38 |
| ▸ | DAPK3 | O43293 | 2/20 | 0.38 |
| ▸ | CHEK2 | O96017 | 2/20 | 0.38 |
| ▸ | CDK1 | P06493 | 2/20 | 0.38 |
| ▸ | PIM1 | P11309 | 2/20 | 0.38 |
| ▸ | CDK2 | P24941 | 2/20 | 0.38 |
| ▸ | MAPK9 | P45984 | 2/20 | 0.38 |
| ▸ | CSNK1D | P48730 | 2/20 | 0.38 |
| ▸ | GSK3A | P49840 | 2/20 | 0.38 |
| ▸ | GSK3B | P49841 | 2/20 | 0.38 |
| ▸ | CSNK2A1 | P68400 | 2/20 | 0.38 |
| ▸ | DYRK1A | Q13627 | 2/20 | 0.38 |
| ▸ | AURKB | Q96GD4 | 2/20 | 0.38 |
| ▸ | PLK3 | Q9H4B4 | 2/20 | 0.38 |
| ▸ | PIM2 | Q9P1W9 | 2/20 | 0.38 |
| ▸ | PRKACA | P17612 | 1/20 | 0.38 |
| ▸ | RPS6KA3 | P51812 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5979776 | 0.72 | GPR35 (0.40) | GPR35BCL2L1DAOKDM4EMEN1 | |
| SCHEMBL26983415 | 0.72 | GPR35 (0.37) | GPR35BCL2L1PLK4AURKADAPK3 | |
| SCHEMBL1310113 | 0.68 | GPR35 (0.68) | GPR35BCL2L1PLK4AURKADAPK3 | |
| SCHEMBL2895320 | 0.67 | GPR35 (0.46) | GPR35BCL2L1PLK4AURKADAPK3 | |
| SCHEMBL16408743 | 0.66 | PKM (0.44) | CSNK1DGSK3AGSK3BCSNK2A1DYRK1A | |
| SCHEMBL28531853 | 0.66 | GPR35 (0.65) | GPR35BCL2L1PLK4AURKADAPK3 | |
| SCHEMBL30643033 | 0.62 | GPR35 (0.76) | GPR35BCL2L1DYRK1ADAOKDM4E | |
| SCHEMBL18549584 | 0.61 | CHEK1 (0.40) | AURKADAPK3GSK3ADYRK1ADAO | |
| SCHEMBL6205077 | 0.61 | GPR35 (0.42) | GPR35BCL2L1PLK4AURKADAPK3 | |
| SCHEMBL12668178 | 0.61 | GPR35 (0.55) | GPR35BCL2L1PLK4AURKADAPK3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1534716-A1 | HETEROBICYCLIC PYRAZOLE DERIVATIVES AS KINASE INHIBITORS | Pharmacia Italia S.p.A. (IT) | 2005-06-01 | — | — | EP | disclosed |
| WO-2004007504-A1 | HETEROBICYCLIC PYRAZOLE DERIVATIVES AS KINASE INHIBITORS | PHARMACIA ITALIA S.P.A. (IT) | 2004-01-22 | — | — | WO | disclosed |