Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ELANE | P08246 | 6/20 | 0.50 |
| ▸ | CES2 | O00748 | 1/20 | 0.43 |
| ▸ | CES1 | P23141 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.40 |
| ▸ | NPC1 | O15118 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | RAB9A | P51151 | 2/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.39 |
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | PKM | P14618 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | ESR1 | P03372 | 1/20 | 0.39 |
| ▸ | RECQL | P46063 | 1/20 | 0.39 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.39 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1145280 | 1.00 | ELANE (0.50) | ELANECES2CES1SMN1; SMN2NPC1 | |
| SCHEMBL6206192 | 1.00 | ELANE (0.50) | ELANECES2CES1SMN1; SMN2NPC1 | |
| SCHEMBL9565752 | 0.81 | KMT2A (0.47) | CES2CES1SMN1; SMN2NPC1ALDH1A1 | |
| SCHEMBL3929746 | 0.80 | ELANE (0.46) | ELANECES2CES1SMN1; SMN2NPC1 | |
| SCHEMBL372385 | 0.79 | ELANE (0.45) | ELANESMN1; SMN2NPC1ALDH1A1RAB9A | |
| SCHEMBL9309718 | 0.78 | ELANE (0.47) | ELANECES2CES1SMN1; SMN2NPC1 | |
| SCHEMBL5698374 | 0.77 | CES1 (0.52) | ELANECES2CES1SMN1; SMN2NPC1 | |
| SCHEMBL11312420 | 0.77 | CES2 (0.41) | ELANECES2CES1SMN1; SMN2NPC1 | |
| SCHEMBL6204752 | 0.77 | ELANE (0.52) | ELANECES2CES1ALDH1A1KMT2A | |
| SCHEMBL9562937 | 0.77 | ELANE (0.52) | ELANECES2CES1ALDH1A1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1532128-A1 | INHIBITORS OF HCV NS5B POLYMERASE | Pharmacia & Upjohn Company LLC (US) | 2005-05-25 | — | — | EP | disclosed |
| WO-2004002977-A1 | INHIBITORS OF HCV NS5B POLYMERASE | PHARMACIA & UPJOHN COMPANY LLC (US) | 2004-01-08 | — | — | WO | disclosed |