Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 8/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.41 |
| ▸ | ALDH1A3 | P47895 | 2/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.37 |
| ▸ | MAPT | P10636 | 4/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.37 |
| ▸ | HPGD | P15428 | 3/20 | 0.37 |
| ▸ | MEN1 | O00255 | 3/20 | 0.37 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.37 |
| ▸ | ALDH3A1 | P30838 | 2/20 | 0.36 |
| ▸ | GAA | P10253 | 2/20 | 0.33 |
| ▸ | USP2 | O75604 | 1/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | PGR | P06401 | 1/20 | 0.32 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.32 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.31 |
| ▸ | KCNMA1 | Q12791 | 1/20 | 0.31 |
| ▸ | POLB | P06746 | 1/20 | 0.30 |
| ▸ | CRHR1 | P34998 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1591771 | 0.84 | MAPT (0.38) | ALDH1A1KDM4EMAPTKMT2AHPGD | |
| SCHEMBL422228 | 0.75 | EPAS1 (0.32) | — | |
| SCHEMBL21922442 | 0.74 | ERN1 (0.38) | ALDH1A1KDM4EKMT2AHPGDMEN1 | |
| SCHEMBL18302305 | 0.71 | TDP1 (0.38) | ALDH1A1L3MBTL1KDM4EMAPTKMT2A | |
| SCHEMBL31550251 | 0.71 | KCNJ1 (0.32) | — | |
| SCHEMBL15776319 | 0.71 | ALDH1A3 (0.45) | ALDH1A1L3MBTL1ALDH1A3KDM4EMAPT | |
| SCHEMBL13144666 | 0.70 | ALDH1A1 (0.56) | ALDH1A1L3MBTL1ALDH1A3KDM4EMAPT | |
| SCHEMBL9393637 | 0.69 | KDM4E (0.36) | ALDH1A1L3MBTL1ALDH1A3KDM4EMAPT | |
| SCHEMBL29023125 | 0.69 | XDH (0.36) | ALDH1A1L3MBTL1KDM4EMAPTHPGD | |
| SCHEMBL20588604 | 0.67 | MEN1 (0.41) | ALDH1A1KDM4EMAPTKMT2AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1534676-B1 | PIPERIDINETRIOL DERIVATIVES AS INHIBITORS OF GLYCOSYLCERAMIDE SYNTHASE | ACTELION PHARMACEUTICALS LTD (CH) | 2012-09-12 | — | — | EP | disclosed |
| EP-1534676-A1 | PIPERIDINETRIOL DERIVATIVES AS INHIBITORS OF GLYCOSYLCERAMIDE SYNTHASE | Oxford GlycoSciences (UK) Limited (GB) | 2005-06-01 | — | — | EP | disclosed |
| WO-2004007453-A1 | PIPERIDINETRIOL DERIVATIVES AS INHIBITORS OF GLYCOSYLCERAMIDE SYNTHASE | OXFORD GLYCOSCIENCES (UK) LTD (GB) | 2004-01-22 | — | — | WO | disclosed |