Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2C | P28335 | 10/20 | 0.50 |
| ▸ | HTR2B | P41595 | 8/20 | 0.50 |
| ▸ | HTR2A | P28223 | 8/20 | 0.50 |
| ▸ | HTR1A | P08908 | 6/20 | 0.50 |
| ▸ | HTR1D | P28221 | 5/20 | 0.50 |
| ▸ | HTR6 | P50406 | 2/20 | 0.50 |
| ▸ | HTR4 | Q13639 | 2/20 | 0.50 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.50 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.50 |
| ▸ | HTR1B | P28222 | 1/20 | 0.50 |
| ▸ | HTR7 | P34969 | 1/20 | 0.50 |
| ▸ | MTNR1A | P48039 | 2/20 | 0.33 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.33 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.31 |
| ▸ | WDR77 | Q9BQA1 | 1/20 | 0.31 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL6202353 | 0.99 | HTR2C (0.49) | HTR2CHTR2BHTR2AHTR1AHTR1D | |
| SCHEMBL6748800 | 0.78 | HTR2C (0.62) | HTR2CHTR2BHTR2AHTR1AHTR1D | |
| Hydrochloric Acid SCHEMBL6751698 | 0.77 | HTR2C (0.61) | HTR2CHTR2BHTR2AHTR1AHTR1D | |
| SCHEMBL7000780 | 0.77 | HTR2C (0.63) | HTR2CHTR2BHTR2AHTR1AHTR1D | |
| SCHEMBL7002281 | 0.77 | HTR2C (0.63) | HTR2CHTR2BHTR2AHTR1AHTR1D | |
| Hydrochloric Acid SCHEMBL6996518 | 0.76 | HTR2C (0.62) | HTR2CHTR2BHTR2AHTR1AHTR1D | |
| SCHEMBL26131147 | 0.73 | HTR2C (0.46) | HTR2CHTR2BHTR2AHTR1AHTR1D | |
| SCHEMBL7001928 | 0.68 | HTR2C (0.67) | HTR2CHTR2BHTR2AHTR1AHTR1D | |
| SCHEMBL6092065 | 0.67 | HTR2C (1.00) | HTR2CHTR2BHTR2AHTR1AHTR1D | |
| SCHEMBL30390274 | 0.67 | HTR2C (1.00) | HTR2CHTR2BHTR2AHTR1AHTR1D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1513521-A2 | PYRANOINDAZOLES AND THEIR USE FOR THE TREATMENT OF GLAUCOMA | Alcon, Inc. (CH) | 2005-03-16 | — | — | EP | claimed |
| WO-2003101379-A2 | PYRANOINDAZOLES AND THEIR USE FOR THE TREATMENT OF GLAUCOMA | ALCON, INC. (CH) | 2003-12-11 | — | — | WO | claimed |
| EP-1513521-A2 | PYRANOINDAZOLES AND THEIR USE FOR THE TREATMENT OF GLAUCOMA | Alcon, Inc. (CH) | 2005-03-16 | — | — | EP | disclosed |
| WO-2003101379-A2 | PYRANOINDAZOLES AND THEIR USE FOR THE TREATMENT OF GLAUCOMA | ALCON, INC. (CH) | 2003-12-11 | — | — | WO | disclosed |