Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 6/20 | 0.46 |
| ▸ | RAB9A | P51151 | 6/20 | 0.46 |
| ▸ | MEN1 | O00255 | 4/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.46 |
| ▸ | MAPT | P10636 | 4/20 | 0.46 |
| ▸ | GLA | P06280 | 2/20 | 0.46 |
| ▸ | TSHR | P16473 | 2/20 | 0.46 |
| ▸ | LMNA | P02545 | 2/20 | 0.46 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.43 |
| ▸ | BLM | P54132 | 3/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | G6PD | P11413 | 1/20 | 0.39 |
| ▸ | USP2 | O75604 | 1/20 | 0.38 |
| ▸ | PKM | P14618 | 1/20 | 0.38 |
| ▸ | PTPRE | P23469 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 2/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
| ▸ | HPN | P05981 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6080170 | 0.95 | NPC1 (0.51) | NPC1RAB9AMEN1KMT2AALDH1A1 | |
| SCHEMBL6309454 | 0.87 | NPC1 (0.43) | NPC1RAB9AMEN1KMT2AALDH1A1 | |
| SCHEMBL6079674 | 0.82 | RAB9A (0.49) | NPC1RAB9AMEN1KMT2AALDH1A1 | |
| SCHEMBL6206155 | 0.77 | MAPK14 (0.49) | NPC1RAB9AMEN1KMT2AMAPT | |
| SCHEMBL6080069 | 0.74 | NOS1 (0.47) | RAB9AMAPTLMNA | |
| SCHEMBL6309458 | 0.74 | NPC1 (0.40) | NPC1RAB9AMEN1KMT2AALDH1A1 | |
| SCHEMBL6204115 | 0.72 | PTPRE (0.41) | NPC1RAB9AMEN1KMT2AALDH1A1 | |
| SCHEMBL6226761 | 0.72 | MAPK14 (0.61) | NPC1RAB9AMEN1KMT2AMAPT | |
| SCHEMBL6079321 | 0.72 | MAPK14 (0.54) | MEN1KMT2AMAPTLMNAMAPK14 | |
| SCHEMBL6078757 | 0.71 | RAB9A (0.56) | NPC1RAB9AMEN1KMT2AALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1545523-A1 | 3-&-grave;(HETERO) ARYLMETHOXY ! PYRIDINES AND THEIR ANALOGUES ASP38 MAP KINASE INHIBITORS | Astex Technology Limited (GB) | 2005-06-29 | — | — | EP | disclosed |
| WO-2004004720-A1 | 3-`(HETERO) ARYLMETHOXY ! PYRIDINES AND THEIR ANALOGUES AS P38 MAP KINASE INHIBITORS | ASTEX TECHNOLOGY LIMITED (GB) | 2004-01-15 | — | — | WO | disclosed |