Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 8/20 | 0.40 |
| ▸ | RAB9A | P51151 | 8/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.37 |
| ▸ | G6PD | P11413 | 1/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | GPR132 | Q9UNW8 | 3/20 | 0.35 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.35 |
| ▸ | NOX1 | Q9Y5S8 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | USP2 | O75604 | 1/20 | 0.33 |
| ▸ | PKM | P14618 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 2/20 | 0.33 |
| ▸ | HPGD | P15428 | 2/20 | 0.33 |
| ▸ | TP53 | P04637 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6309454 | 0.78 | NPC1 (0.43) | NPC1RAB9AALDH1A1SMN1; SMN2G6PD | |
| SCHEMBL6080170 | 0.78 | NPC1 (0.51) | NPC1RAB9AALDH1A1SMN1; SMN2G6PD | |
| SCHEMBL6205063 | 0.74 | NPC1 (0.46) | NPC1RAB9AALDH1A1SMN1; SMN2G6PD | |
| SCHEMBL6079674 | 0.66 | RAB9A (0.49) | NPC1RAB9AALDH1A1SMN1; SMN2MAPK1 | |
| SCHEMBL6206155 | 0.63 | MAPK14 (0.49) | NPC1RAB9ASMN1; SMN2KDM4EMEN1 | |
| SCHEMBL6230436 | 0.62 | SIRT2 (0.57) | RAB9ASIRT2SIRT1SIRT3 | |
| SCHEMBL19702030 | 0.61 | NOS1 (0.50) | NPC1RAB9ASMN1; SMN2MAPK1GPR132 | |
| SCHEMBL6080064 | 0.60 | MAOB (0.53) | SMN1; SMN2KMT2ASIRT2SIRT1SIRT3 | |
| SCHEMBL6078757 | 0.60 | RAB9A (0.56) | NPC1RAB9AALDH1A1SMN1; SMN2MEN1 | |
| SCHEMBL6078971 | 0.60 | MAPK14 (0.56) | MAPK1SIRT2SIRT1SIRT3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2005002673-A1 | RAF KINASE INHIBITORS | ASTEX THERAPEUTICS LIMITED (GB) | 2005-01-13 | — | — | WO | disclosed |