Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DPP4 | P27487 | 15/20 | 0.44 |
| ▸ | DPP7 | Q9UHL4 | 7/20 | 0.41 |
| ▸ | DPP9 | Q86TI2 | 7/20 | 0.40 |
| ▸ | DPP8 | Q6V1X1 | 7/20 | 0.40 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.38 |
| ▸ | MMP1 | P03956 | 1/20 | 0.38 |
| ▸ | MMP2 | P08253 | 1/20 | 0.38 |
| ▸ | MMP9 | P14780 | 1/20 | 0.38 |
| ▸ | MMP12 | P39900 | 1/20 | 0.38 |
| ▸ | CES2 | O00748 | 2/20 | 0.37 |
| ▸ | CES1 | P23141 | 2/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6204307 | 0.86 | IDO1 (0.46) | DPP4DPP7RIPK1CES2CES1 | |
| SCHEMBL24876469 | 0.83 | NR3C1 (0.38) | — | |
| SCHEMBL451227 | 0.79 | DPP4 (0.47) | DPP4DPP7DPP9DPP8RIPK1 | |
| SCHEMBL439644 | 0.79 | DPP4 (0.47) | DPP4DPP7DPP9DPP8RIPK1 | |
| SCHEMBL6205089 | 0.79 | DPP4 (0.47) | DPP4DPP7DPP9DPP8RIPK1 | |
| SCHEMBL6201421 | 0.78 | IDO1 (0.42) | — | |
| SCHEMBL441142 | 0.76 | DPP4 (0.56) | DPP4DPP7DPP9DPP8 | |
| SCHEMBL439656 | 0.76 | DPP4 (0.56) | DPP4DPP7DPP9DPP8 | |
| SCHEMBL8250509 | 0.75 | DPP4 (0.50) | DPP4DPP7DPP9DPP8RIPK1 | |
| SCHEMBL8310385 | 0.74 | DPP4 (0.44) | DPP4DPP7DPP9DPP8RIPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1506175-A1 | N-SUBSTITUTED TRICYCLIC 3-AMINOPYRAZOLES AS PDGF RECEPTOR INHIBITORS | JANSSEN PHARMACEUTICA N.V. (BE) | 2005-02-16 | — | — | EP | disclosed |
| WO-2003097609-A1 | N-SUBSTITUTED TRICYCLIC 3-AMINOPYRAZOLES AS PDFG RECEPTOR INHIBITORS | JANSSEN PHARMACEUTICA N.V. (BE) | 2003-11-27 | — | — | WO | disclosed |