Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DPP4 | P27487 | 17/20 | 0.47 |
| ▸ | DPP7 | Q9UHL4 | 8/20 | 0.41 |
| ▸ | DPP9 | Q86TI2 | 8/20 | 0.41 |
| ▸ | DPP8 | Q6V1X1 | 7/20 | 0.41 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.38 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.38 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.38 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.38 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.38 |
| ▸ | PSENEN | Q9NZ42 | 1/20 | 0.38 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6204303 | 0.86 | IDO1 (0.46) | DPP4DPP7RIPK1 | |
| SCHEMBL6205091 | 0.79 | DPP4 (0.44) | DPP4DPP7DPP9DPP8RIPK1 | |
| SCHEMBL6201417 | 0.78 | IDO1 (0.42) | — | |
| SCHEMBL8250509 | 0.75 | DPP4 (0.50) | DPP4DPP7DPP9DPP8PSEN1 | |
| SCHEMBL6205901 | 0.73 | TRPA1 (0.46) | — | |
| SCHEMBL6203594 | 0.73 | MAOA (0.40) | DPP4DPP7RIPK1 | |
| SCHEMBL22636115 | 0.72 | DPP4 (0.48) | DPP4DPP7DPP9DPP8 | |
| SCHEMBL22636113 | 0.72 | DPP4 (0.48) | DPP4DPP7DPP9DPP8 | |
| SCHEMBL861831 | 0.72 | RIPK1 (0.50) | DPP4DPP7DPP9DPP8PSEN1 | |
| SCHEMBL441142 | 0.72 | DPP4 (0.56) | DPP4DPP7DPP9DPP8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1506175-A1 | N-SUBSTITUTED TRICYCLIC 3-AMINOPYRAZOLES AS PDGF RECEPTOR INHIBITORS | JANSSEN PHARMACEUTICA N.V. (BE) | 2005-02-16 | — | — | EP | disclosed |
| WO-2003097609-A1 | N-SUBSTITUTED TRICYCLIC 3-AMINOPYRAZOLES AS PDFG RECEPTOR INHIBITORS | JANSSEN PHARMACEUTICA N.V. (BE) | 2003-11-27 | — | — | WO | disclosed |